Document Detail


Does vitamin D modulate blood pressure?
MedLine Citation:
PMID:  23299053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Both vitamin D deficiency and hypertension are highly prevalent. It is unclear whether vitamin D modulates blood pressure and therefore whether vitamin D testing and therapy should become part of routine hypertension prevention and management. This article provides an overview of the data, with special emphasis on the work published in the last 2 years.
RECENT FINDINGS: Several animal studies corroborate the strong effect of vitamin D on the renin-angiotensin-aldosterone axis. Small and large observational studies have found associations between vitamin D, increased blood pressure, and the risk of developing hypertension. In contrast, recent data from randomized trials are mixed. Two randomized trials with approximately 1 year of follow-up detected no association between vitamin D treatment and blood pressure, whereas another study of active vitamin D reported a 9-mmHg decrease in systolic blood pressure. Meta-analyses have linked vitamin D levels with blood pressure, but the effect of vitamin D administration on blood pressure remains controversial.
SUMMARY: Vitamin D deficiency is asociated with high blood pressure in observational studies. This effect is thought to be partly mediated through regulation of the renin-angiotensin-aldosterone axis. However, randomized clinical trials and their meta-analyses have yielded inconclusive results. Large randomized trials focusing on patients with severe vitamin D deficiency and hypertension are needed before vitamin D can be recommended for the prevention or treatment of hypertension.
Authors:
Hector Tamez; Sahir Kalim; Ravi I Thadhani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  22     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-26     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Dietary Supplements
Humans
Hypertension / blood*,  drug therapy,  metabolism,  physiopathology
Renin-Angiotensin System
Treatment Outcome
Vitamin D / blood*,  therapeutic use
Vitamin D Deficiency / blood*,  drug therapy,  epidemiology,  physiopathology
Vitamins / therapeutic use
Grant Support
ID/Acronym/Agency:
K24 DK094872/DK/NIDDK NIH HHS; K24 DK094872/DK/NIDDK NIH HHS; R01 DK094486/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Vitamins; 1406-16-2/Vitamin D
Comments/Corrections

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