Document Detail

Does viloxazine have epileptogenic properties?
MedLine Citation:
PMID:  6434699     Owner:  NLM     Status:  MEDLINE    
Six cases of convulsive seizures occurring during treatment with viloxazine notified to the Committee on Safety of Medicines (CSM) and two other cases from Japan were reviewed. A critical study of the patient's histories suggests a possible causal connection between drug and seizures in only two of these cases. The occurrence of convulsions is not in keeping with the results of animal experiments and of clinical trials in which epileptic patients were included, both of which suggest that viloxazine does not have epileptogenic properties and may have anticonvulsant actions. A worldwide review of clinical trials in which unwanted effects have been recorded suggests that viloxazine, even if possessing convulsive properties like other anti-depressants, is probably less epileptogenic than conventional tricyclics and is not contraindicated in epileptic patients requiring antidepressant medication.
J G Edwards; M Glen-Bott
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  47     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-11-20     Completed Date:  1984-11-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  960-4     Citation Subset:  IM    
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MeSH Terms
Depressive Disorder / drug therapy*
Drug Therapy, Combination
Epilepsy, Tonic-Clonic / chemically induced*
Middle Aged
Morpholines / adverse effects*
Seizures / chemically induced
Viloxazine / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Morpholines; 46817-91-8/Viloxazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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