Document Detail

Does the use of paclitaxel or rapamycin-eluting stent decrease further need for coronary-artery bypass grafting when compared with bare-metal stent?
MedLine Citation:
PMID:  17992397     Owner:  NLM     Status:  MEDLINE    
CONTEXT AND OBJECTIVE: The safety and efficacy of drug-eluting stents reduce the need for surgical revascularization. The objective of the present study was to investigate whether paclitaxel or rapamycin-eluting stent are effective in avoiding the need for coronary-artery bypass grafting. METHODS: This was a systematic review of the literature using the methodology of the Cochrane Collaboration. The type of study considered was controlled randomized trials; the type of intervention was drug-eluting or bare-metal stents; and the main outcome investigated was coronary-artery bypass grafting. RESULTS: The ten studies included in this systematic review did not show any statistically significant difference between the drug-eluting stents and the bare-metal stents with regard to the outcome of coronary-artery bypass grafting (confidence interval: 0.31 to 1.42). CONCLUSION: The surgical revascularization rate was not reduced by the use of drug-eluting stents.
Hernani Pinto de Lemos Jr; Alvaro Nagib Atallah
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  São Paulo medical journal = Revista paulista de medicina     Volume:  125     ISSN:  1516-3180     ISO Abbreviation:  Sao Paulo Med J     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-11-09     Completed Date:  2008-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897261     Medline TA:  Sao Paulo Med J     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  242-5     Citation Subset:  IM    
Brazilian Cochrane Center, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, Brazil.
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MeSH Terms
Coronary Artery Bypass*
Coronary Restenosis / prevention & control*
Cytostatic Agents / administration & dosage*
Drug-Eluting Stents
Paclitaxel / administration & dosage*
Randomized Controlled Trials as Topic
Sirolimus / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Cytostatic Agents; 33069-62-4/Paclitaxel; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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