Document Detail

Does uric acid qualify as an independent risk factor for cardiovascular mortality?
MedLine Citation:
PMID:  23043434     Owner:  NLM     Status:  MEDLINE    
UA (uric acid) is the final product of purine metabolism in humans and is implicated in many disease conditions. Sustained hyperuricaemia has putative adverse roles in cardiovascular diseases. Despite strong evidence emerging from large epidemiological studies supporting the hypothesis that UA independently influences cardiovascular disease outcomes and mortality, a causal role is yet to be established. Serum UA is also considered as a useful biomarker for mortality in high-risk patients with acute coronary syndromes, heart failure and hypertension and in patients with Type 2 diabetes mellitus. Post-hoc analyses of clinical trial data suggest beneficial effects of reducing serum UA. However, these findings are inconclusive and are only hypothesis-generating. In the present issue of Clinical Science, Ndrepepa and co-workers have investigated the prognostic role of UA in high-risk Type 2 diabetic patients with established coronary artery disease in predicting 1-year survival and cardiovascular mortality. These results support the independent role of serum UA in predicting survival in Type 2 diabetic patients. However, long-term follow-up studies are required with serial UA measurement to establish the time-dependent association of UA with mortality outcomes.
Panniyammakal Jeemon; Dorairaj Prabhakaran
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  124     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-11-06     Completed Date:  2013-01-10     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-7     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Coronary Artery Disease / blood,  complications,  mortality*
Diabetes Mellitus, Type 2 / blood,  complications
Hyperuricemia / complications*,  diagnosis
Risk Factors
Uric Acid / blood
Grant Support
084754//Wellcome Trust; 1D43HD065249/HD/NICHD NIH HHS; HHSN286200900026C//PHS HHS; //Wellcome Trust
Reg. No./Substance:
0/Biological Markers; 268B43MJ25/Uric Acid

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