Document Detail


Does unwantedness of pregnancy predict schizophrenia in the offspring? Findings from a prospective birth cohort study.
MedLine Citation:
PMID:  16732398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We sought to replicate (or refute) a previous report of an association between unwantedness of a pregnancy and the risk of schizophrenia in the offspring.
METHOD: The study was conducted using a large, prospectively collected birth cohort as part of the Prenatal Determinants of Schizophrenia study (PDS). Attitude toward the pregnancy was assessed at the time of the mother's first visit to the prenatal clinic. Cases of schizophrenia and other schizophrenia spectrum disorders in the offspring of these mothers were subsequently ascertained and diagnosed. In univariate and multivariate analyses, we examined the relationship between attitude toward the pregnancy and risk of adult schizophrenia and other schizophrenia spectrum disorders.
RESULTS: The unadjusted hazard ratio for the association between ambivalent or negative maternal attitude toward the pregnancy and the risk of schizophrenia spectrum disorders was 1.75, (95% CI=0.97, 3.17, P=0.06). This result was unchanged after adjustment for social class, paternal age, race/ethnicity and other potential confounders. Similar results were observed when only cases with schizophrenia were included in the analysis.
CONCLUSIONS: We did not find a statistically significant association in favor of the hypothesis that unwantedness of pregnancy is a risk factor for adult schizophrenia. On the other hand, the magnitude of the observed association was similar to the findings of the only previous study of this question and the confidence limits overlap those findings. Whether unwantedness of pregnancy is a risk factor for adult schizophrenia remains an open question that may be resolved by future research.
Authors:
Daniel B Herman; Alan S Brown; Mark G Opler; Manisha Desai; Dolores Malaspina; Michaeline Bresnahan; Catherine A Schaefer; Ezra S Susser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-05-26
Journal Detail:
Title:  Social psychiatry and psychiatric epidemiology     Volume:  41     ISSN:  0933-7954     ISO Abbreviation:  Soc Psychiatry Psychiatr Epidemiol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-18     Completed Date:  2007-05-08     Revised Date:  2012-05-11    
Medline Journal Info:
Nlm Unique ID:  8804358     Medline TA:  Soc Psychiatry Psychiatr Epidemiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  605-10     Citation Subset:  IM    
Affiliation:
New York State Psychiatric Institute, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Demography
Female
Follow-Up Studies
Humans
Infant
Mothers / psychology,  statistics & numerical data
Pregnancy
Pregnancy, Unwanted / psychology*
Prenatal Exposure Delayed Effects / epidemiology*,  psychology
Prevalence
Prospective Studies
Risk Factors
Schizophrenia / epidemiology*
Stress, Psychological / epidemiology
Grant Support
ID/Acronym/Agency:
1K02MH65422-01/MH/NIMH NIH HHS; 1R01MH-60249/MH/NIMH NIH HHS; 1R01MH63264/MH/NIMH NIH HHS; K02 MH065422/MH/NIMH NIH HHS; N01-HD-1-3334/HD/NICHD NIH HHS; N01-HD-6-3258/HD/NICHD NIH HHS

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