| Does undetectable basal Tg measured with a highly sensitive assay in the absence of antibodies and combined with normal ultrasonography ensure the absence of disease in patients treated for thyroid carcinoma? | |
| | |
MedLine Citation:
|
PMID: 22584569 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
It has been proposed that, in patients treated for well-differentiated thyroid carcinoma, undetectable basal thyroglobulin (Tg) levels measured with a highly sensitive assay in the absence of anti-thyroglobulin antibodies (TgAb) and combined with negative neck ultrasonography (US) ensured the absence of disease. We report a series of five patients with well-differentiated (papillary) carcinoma submitted to total thyroidectomy with apparently complete tumor resection, followed by remnant ablation with 131I (100-150 mCi), who had no distant metastases upon initial post-therapy whole-body scanning. When tumor recurrence or persistence was detected, these patients presented undetectable basal Tg (0.1 ng/mL) in the absence of TgAb, and US showed no anomalies. Two patients had lymph node metastases, one had mediastinal metastases, bone involvement was observed in one patient, and local recurrence in one. We conclude that further studies are needed to define in which patients undetectable basal Tg (negative TgAb) combined with negative US is sufficient, and no additional tests are required. |
| | |
Authors:
|
Pedro Weslley Rosário; Augusto Flávio Campos Mineiro Filho |
Related Documents
:
|
22318909 - Leukocyte telomere length predicts overall survival in hepatocellular carcinoma treated... 10023309 - Prognostic factors in soft tissue sarcomas: the aarhus experience. 22577889 - Long-term survival of high-risk melanoma patients immunized with a hyper-il-6-modified ... 22864889 - Repeat hepatic resection for colorectal liver metastases. 10527599 - Isolated limb perfusion with tumour necrosis factor-alpha and melphalan for unresectabl... 22403699 - Strengths and weaknesses of immunotherapy for advanced non-small-cell lung cancer: a me... 18484429 - Atypical fibroxanthoma presenting in a patient with stage iii mycosis fungoides. 14765389 - Radiotherapy for malignant gliomas in the elderly. 17066609 - Carcinoid tumours in the gastrointestinal tract--a population-based study from western ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Arquivos brasileiros de endocrinologia e metabologia Volume: 56 ISSN: 1677-9487 ISO Abbreviation: Arq Bras Endocrinol Metabol Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-05-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0403437 Medline TA: Arq Bras Endocrinol Metabol Country: Brazil |
Other Details:
|
Languages: eng Pagination: 149-51 Citation Subset: IM |
Affiliation:
|
Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [Overweight and obesity in school children: association between biopsychological, socioeconomic and ...
Next Document: Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Stauf...