Document Detail

Does transient hypothyroxinemia cause abnormal neurodevelopment in premature infants?
MedLine Citation:
PMID:  9779338     Owner:  NLM     Status:  MEDLINE    
THOP is a relatively common condition whose long-term effects remain uncertain. The preponderance of evidence indicates that at the very least THOP is a marker of elevated risk of neurodevelopmental adversity, but whether this association is truly causal and whether thyroxine treatment in the neonatal period can prevent adverse outcome is as yet unknown. Since the number of infants born and surviving at very early gestations continues to increase, the importance of this condition will be magnified in the future. The major difficulty in establishing the causal role of THOP is the tangled time order of events in the early neonatal period. It is therefore unlikely that further observational studies will advance understanding. Energies should be focused on Assessing neurodevelopment objectively in survivors in each of the TRH trials. Developing a new multicenter trial of newborn supplementation with thyroid hormone that is carefully planned to have sufficient power to assess neurodevelopment in treated and untreated infants under a variety of baseline conditions.
N Paneth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics in perinatology     Volume:  25     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-03     Completed Date:  1998-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  627-43     Citation Subset:  IM    
Department of Epidemiology, College of Human Medicine, Michigan State University, East Lansing, USA.
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MeSH Terms
Developmental Disabilities / etiology*
Infant, Newborn
Infant, Premature / blood*
Neonatal Screening
Research Design
Risk Factors
Thyroxine / blood,  deficiency*,  therapeutic use
Time Factors
Reg. No./Substance:

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