Document Detail

Does total antioxidant status relate to outcome in very preterm infants?
MedLine Citation:
PMID:  9536929     Owner:  NLM     Status:  MEDLINE    
1. In healthy humans, a balance exists between oxygen-derived free-radical production and their removal by antioxidants. In preterm infants inadequate antioxidant defences may contribute to the pathogenesis of some of the complications of prematurity. 2. Plasma total antioxidant status and malondialdehyde concentration were measured during the first 11 days of life in 25 infants to determine whether increased lipid peroxidation is associated with low extracellular antioxidant status. In a second group of infants, total antioxidant status was quantified within 12 h of birth, and subsequently on days 4 and 10 to investigate the hypothesis that adverse neonatal outcome is associated with low antioxidant status. 3. There may be a weak negative correlation between the total antioxidant status of infants and the lipid peroxidation marker malondialdehyde in plasma (r = -0.24, P = 0.056, n = 89) during the first 11 days of life. In the second group of infants, total antioxidant status was found to be significantly related to plasma urate and bilirubin levels, but not to adverse neonatal outcomes such as chronic lung disease, intraventricular haemorrhage, retinopathy of prematurity or death. 4. If adverse neonatal outcomes are due to inadequate antioxidant defences, these are likely to be intracellular or localized rather than general extracellular deficiencies.
J A Drury; J A Nycyk; M Baines; R W Cooke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  94     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-21     Completed Date:  1998-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  197-201     Citation Subset:  IM    
Department of Child Health, University of Liverpool, Liverpool Women's Hospital, U.K.
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MeSH Terms
Antioxidants / analysis*
Bilirubin / blood
Follow-Up Studies
Gestational Age
Infant, Newborn
Infant, Premature / blood*
Infant, Premature, Diseases / blood*,  therapy
Lipid Peroxidation
Malondialdehyde / blood*
Nutritional Status
Respiration, Artificial
Statistics, Nonparametric
Uric Acid / blood
Reg. No./Substance:
0/Antioxidants; 542-78-9/Malondialdehyde; 635-65-4/Bilirubin; 69-93-2/Uric Acid

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