Document Detail

Does terbutaline damage the developing heart?
MedLine Citation:
PMID:  14745978     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Beta(2)-Adrenoceptor (betaAR) agonists, such as terbutaline, are widely used to arrest preterm labor. They also cross the placenta where they stimulate receptors in fetal tissues, which in turn use betaAR input for trophic control of cell replication and differentiation. METHODS: As rats are altricial, we administered terbutaline in two different postnatal exposure periods (10 mg/kg given daily on Days 2-5 or 11-14). RESULTS: Hearts were examined twenty-four hours after the last dose and on postnatal day 30 for cardiac damage. Neither treatment paradigm caused an increase in cardiac abnormalities compared to controls but quantitative analysis of the number of nuclei indicated reductions in females. CONCLUSIONS: These findings do not support earlier case reports of outright myocardial necrosis after terbutaline tocolysis in human infants. Nevertheless, the significant statistical association between terbutaline and cardiac anomalies in epidemiological studies suggest that terbutaline may sensitize the developing heart to other insults that affect development.
Melissa C Rhodes; Abraham Nyska; Frederic J Seidler; Theodore A Slotkin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Birth defects research. Part B, Developmental and reproductive toxicology     Volume:  68     ISSN:  1542-9733     ISO Abbreviation:  Birth Defects Res. B Dev. Reprod. Toxicol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-27     Completed Date:  2004-08-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101155115     Medline TA:  Birth Defects Res B Dev Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  449-55     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
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MeSH Terms
Adrenergic beta-Agonists / metabolism
Cell Nucleus / metabolism
Heart / drug effects*,  embryology*
Myocardium / pathology
Pregnancy, Animal
Receptors, Adrenergic, beta / metabolism
Terbutaline / pharmacology*
Time Factors
Tocolytic Agents / pharmacology*
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Receptors, Adrenergic, beta; 0/Tocolytic Agents; 23031-25-6/Terbutaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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