| Does telomere length mediate associations between inbreeding and increased risk for bipolar I disorder and schizophrenia? | |
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MedLine Citation:
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PMID: 21300409 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have recently found that consanguinity is a risk factor for bipolar I disorder (BP1) and schizophrenia (SZ) in Egypt. Inbreeding has been associated with increased cellular stress and impaired physiological function in plants and animals. Previous studies have reported that telomere length (TL), an index of oxidative stress and cellular senescence is significantly reduced among patients with SZ or mood disorders compared with control individuals. Hence we evaluated TL as a possible mediator of the observed association between consanguinity and BP1/SZ risk. Patients with BP1 (n=108), or SZ (n=60) were compared with screened adult controls in separate experiments. TL was estimated using a quantitative PCR (qPCR) based assay. The inbreeding coefficient/consanguinity rate was estimated in two ways: using 64 DNA polymorphisms ('DNA-based' rate); and from family history data ('self report'). Significant correlation between TL and DNA based inbreeding was not observed overall, though suggestive trends were present among the SZ cases. No significant case-control differences in TL were found after controlling for demographic variables. In conclusion, reduced TL may not explain a significant proportion of observed associations between consanguinity and risk for BP1/SZ. |
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Authors:
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Hader Mansour; Kodavali Chowdari; Warda Fathi; Mai Elassy; Ibtihal Ibrahim; Joel Wood; Mikhil Bamne; Salwa Tobar; Amal Yassin; Hala Salah; Hanan Elsayed; Ahmed Eissa; Hala El-Boraie; Nahed E Ibrahim; Mohamed Elsayed; Wafaa El-Bahaei; Zeinab Gomaa; Farha El-Chennawi; Vishwajit L Nimgaonkar |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-5 |
Journal Detail:
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Title: Psychiatry research Volume: - ISSN: 0165-1781 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, United States; Department of Psychiatry, Mansoura University School of Medicine, Mansoura, Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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