Document Detail

Does sympathoadrenal activity predict changes in body fat? An 18-y follow-up study.
MedLine Citation:
PMID:  18541545     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Whether alterations in the sympathoadrenal system contribute to obesity or, rather, are consequences of it, is an unresolved issue. OBJECTIVE: We hypothesized that the sympathoadrenal system plays a predictive role in the development of body fat. DESIGN: At entry, arterial plasma epinephrine and norepinephrine concentrations were measured in 99 healthy men (x +/- SD age: 19.3 +/- 0.4 y) at rest and during a mental stress test and a cold pressor test. Body mass index (BMI; in kg/m(2)), waist circumference, and triceps skinfold thickness were measured at entry and after 18 y of follow-up. RESULTS: Eighty subjects (81%) were available for follow-up analyses after a mean (+/-SD) of 18.0 +/- 0.9 y. The epinephrine responses to the mental stress test (E(MST)) showed a negative relation to changes in BMI (P = 0.01) and waist circumference (P = 0.007). The mean increase in BMI was 6.3 among subjects in the lowest E(MST) quartile and 3.7 in the remaining subjects. In multiple regression analyses corrected for level of exercise, BMI, waist circumference, and triceps skinfold thickness at entry, E(MST) was found to be a consistent negative predictor of future BMI (P = 0.005), waist circumference (P = 0.001), and triceps skinfold thickness (P = 0.05). CONCLUSIONS: We present the first long-term follow-up study in whites showing that the epinephrine response to mental stress is a negative predictor of future BMI, waist circumference, and triceps skinfold thickness after 18 y of follow-up. These findings may provide further insights into the pathophysiology of obesity.
Arnljot Flaa; Leiv Sandvik; Sverre E Kjeldsen; Ivar K Eide; Morten Rostrup
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  87     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-08-01     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1596-601     Citation Subset:  AIM; IM    
Department of Acute Medicine, Cardiovascular and Renal Research Center, Ullevaal University Hospital, Oslo, Norway.
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MeSH Terms
Adipose Tissue / anatomy & histology*
Adrenal Glands / growth & development,  physiology*
Blood Glucose / analysis
Blood Pressure
Body Mass Index
Cholesterol / blood
Epinephrine / blood*
Follow-Up Studies
Heart Rate
Norepinephrine / blood
Sympathetic Nervous System / growth & development,  physiology*
Time Factors
Reg. No./Substance:
0/Blood Glucose; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 57-88-5/Cholesterol

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