| Does sympathoadrenal activity predict changes in body fat? An 18-y follow-up study. | |
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MedLine Citation:
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PMID: 18541545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Whether alterations in the sympathoadrenal system contribute to obesity or, rather, are consequences of it, is an unresolved issue. OBJECTIVE: We hypothesized that the sympathoadrenal system plays a predictive role in the development of body fat. DESIGN: At entry, arterial plasma epinephrine and norepinephrine concentrations were measured in 99 healthy men (x +/- SD age: 19.3 +/- 0.4 y) at rest and during a mental stress test and a cold pressor test. Body mass index (BMI; in kg/m(2)), waist circumference, and triceps skinfold thickness were measured at entry and after 18 y of follow-up. RESULTS: Eighty subjects (81%) were available for follow-up analyses after a mean (+/-SD) of 18.0 +/- 0.9 y. The epinephrine responses to the mental stress test (E(MST)) showed a negative relation to changes in BMI (P = 0.01) and waist circumference (P = 0.007). The mean increase in BMI was 6.3 among subjects in the lowest E(MST) quartile and 3.7 in the remaining subjects. In multiple regression analyses corrected for level of exercise, BMI, waist circumference, and triceps skinfold thickness at entry, E(MST) was found to be a consistent negative predictor of future BMI (P = 0.005), waist circumference (P = 0.001), and triceps skinfold thickness (P = 0.05). CONCLUSIONS: We present the first long-term follow-up study in whites showing that the epinephrine response to mental stress is a negative predictor of future BMI, waist circumference, and triceps skinfold thickness after 18 y of follow-up. These findings may provide further insights into the pathophysiology of obesity. |
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Authors:
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Arnljot Flaa; Leiv Sandvik; Sverre E Kjeldsen; Ivar K Eide; Morten Rostrup |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 87 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-10 Completed Date: 2008-08-01 Revised Date: 2009-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1596-601 Citation Subset: AIM; IM |
Affiliation:
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Department of Acute Medicine, Cardiovascular and Renal Research Center, Ullevaal University Hospital, Oslo, Norway. arnljot.flaa@medisin.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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anatomy & histology* Adrenal Glands / growth & development, physiology* Adult Blood Glucose / analysis Blood Pressure Body Mass Index Cholesterol / blood Epinephrine / blood* Follow-Up Studies Heart Rate Humans Male Norepinephrine / blood Norway Sympathetic Nervous System / growth & development, physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 57-88-5/Cholesterol |
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