Document Detail

Does surfactant type cause a differential proinflammatory response in preterm infants with respiratory distress syndrome?
MedLine Citation:
PMID:  20586001     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The objective of this study was to compare the pulmonary inflammatory response of premature infants with respiratory distress following instillation of one of two commonly available surfactant preparations.
METHODS: This was a prospective, randomized investigation of preterm infants who were less than 30 weeks of gestational age, weighed less than 1 kg at birth, and who qualified to receive surfactant. Infants with multiple congenital anomalies or whose mothers were taking anti-inflammatory medications were ineligible. Tracheal aspirates (TAs) were collected on days 1, 3, 5, and 7 and airway cytokines from TAs were assayed for interleukin (IL)-8 and IL-6.
RESULTS: Infants were evenly matched by gestation (26+/-2 days and 26+/-1 days [mean+/-SD], Surfactant A and B, respectively) and birth weight (730+/-141 g and 732+/-167 g). TA cytokine levels were not different between or within groups. Ventilator requirements and clinical outcomes were similar between the two groups.
CONCLUSION: The postnatal airway inflammatory response observed in preterm infants is not altered by the instillation of either surfactant preparation.
Vanessa V Mercado; Ioana Cristea; Noorjahan Ali; Chau Chau Pham; Elizabeth Buescher; Jean Yang; Joie Fisher; Hima Maramreddy; Johanna Calo; Sonya Strassberg; Lance A Parton
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-06-28
Journal Detail:
Title:  Advances in therapy     Volume:  27     ISSN:  1865-8652     ISO Abbreviation:  Adv Ther     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  476-82     Citation Subset:  T    
Maria Fareri Children's Hospital, New York Medical College, Valhalla, NY 10595, USA.
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MeSH Terms
Cytokines / metabolism*
Infant, Newborn
Infant, Premature*
Interleukin-6 / metabolism
Interleukin-8 / metabolism
Pulmonary Surfactants / therapeutic use*
Respiratory Distress Syndrome, Newborn / drug therapy,  metabolism*,  physiopathology
Respiratory Physiological Processes
Trachea / metabolism
Reg. No./Substance:
0/Cytokines; 0/Interleukin-6; 0/Interleukin-8; 0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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