| Does sucralfate prevent short-term NSAID induced damage to the gastroduodenal mucosa? | |
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MedLine Citation:
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PMID: 7705552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the study was to assess whether sucralfate can prevent or diminish short-term nonsteroidal anti-inflammatory drug (NSAID)-induced damage in the stomach and duodenum. Sixteen healthy subjects were randomly treated for 7 days with sucralfate 2 g b.d. or placebo in a double-blind cross-over manner. Naproxen 500 mg b.d. was given on days 3-7. Gastrointestinal endoscopy was performed before and after each treatment period. Mucosal damage was measured by counting erosions, submucosal hemorrhages or ulcers on a fixed point scale of 0-4 for stomach and duodenum separately. The mean posttreatment injury score in the stomach was 2.13 +/- 1.51 and 2.0 +/- 0.97 for the placebo and sucralfate periods, respectively (p = 0.72). The possibility of type II error was 7%. In the duodenum, the injury score was 1.69 +/- 1.08 and 1.06 +/- 0.93 for the placebo and sucralfate periods, respectively (p = 0.08). The possibility of type II error was 37%. Sucralfate has no efficacy as a prophylactic agent against short-term NSAID-induced gastroduodenal injury. |
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Authors:
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H Gudjónsson; E Oddsson; B Thjodleifsson |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestion Volume: 55 ISSN: 0012-2823 ISO Abbreviation: Digestion Publication Date: 1994 |
Date Detail:
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Created Date: 1995-05-08 Completed Date: 1995-05-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 395-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Landspítalinn, National Hospital, Reykjavík, Iceland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents, Non-Steroidal / adverse effects* Cross-Over Studies Double-Blind Method Drug Interactions Duodenum / drug effects, pathology Female Gastric Mucosa / drug effects*, pathology Gastrointestinal Diseases / chemically induced*, prevention & control* Humans Intestinal Mucosa / drug effects*, pathology Male Stomach / drug effects, pathology Sucralfate / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 54182-58-0/Sucralfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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