Document Detail

Does sucralfate prevent short-term NSAID induced damage to the gastroduodenal mucosa?
MedLine Citation:
PMID:  7705552     Owner:  NLM     Status:  MEDLINE    
The objective of the study was to assess whether sucralfate can prevent or diminish short-term nonsteroidal anti-inflammatory drug (NSAID)-induced damage in the stomach and duodenum. Sixteen healthy subjects were randomly treated for 7 days with sucralfate 2 g b.d. or placebo in a double-blind cross-over manner. Naproxen 500 mg b.d. was given on days 3-7. Gastrointestinal endoscopy was performed before and after each treatment period. Mucosal damage was measured by counting erosions, submucosal hemorrhages or ulcers on a fixed point scale of 0-4 for stomach and duodenum separately. The mean posttreatment injury score in the stomach was 2.13 +/- 1.51 and 2.0 +/- 0.97 for the placebo and sucralfate periods, respectively (p = 0.72). The possibility of type II error was 7%. In the duodenum, the injury score was 1.69 +/- 1.08 and 1.06 +/- 0.93 for the placebo and sucralfate periods, respectively (p = 0.08). The possibility of type II error was 37%. Sucralfate has no efficacy as a prophylactic agent against short-term NSAID-induced gastroduodenal injury.
H Gudjónsson; E Oddsson; B Thjodleifsson
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestion     Volume:  55     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1994  
Date Detail:
Created Date:  1995-05-08     Completed Date:  1995-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
Department of Medicine, Landspítalinn, National Hospital, Reykjavík, Iceland.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Cross-Over Studies
Double-Blind Method
Drug Interactions
Duodenum / drug effects,  pathology
Gastric Mucosa / drug effects*,  pathology
Gastrointestinal Diseases / chemically induced*,  prevention & control*
Intestinal Mucosa / drug effects*,  pathology
Stomach / drug effects,  pathology
Sucralfate / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 54182-58-0/Sucralfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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