Document Detail

Does subepithelial hemorrhage cause persistence of laryngeal granuloma?
MedLine Citation:
PMID:  18197133     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the incidence of black spots after resolution of laryngeal granuloma (LG), to compare the disease duration from the beginning of treatment to resolution between patients with and without black spots, and to assess the histologic findings of LG in resected or biopsied specimens. STUDY DESIGN: Retrospective. METHODS: Forty-six patients with LG on the cartilaginous portion of the vocal fold were included. Their clinical records were reviewed. Histologic specimens were re-examined. RESULTS: Causes of LG were postintubation in 10 patients, unilateral vocal fold immobility in 1, Candida infection in 1, and were not specified in 34 (either hyperfunctional vocal abuse, laryngopharyngeal regurgitation, or both). Of the 10 patients with postintubation LG, 9 resolved; of the 33 patients with LG from other causes, 21 resolved. Of the 28 resolved patients, 12 developed a black spot at the previous lesion site. Of the 18 patients whose LG resolved without surgical intervention, 11 developed a black spot at the previous lesion site, and the remaining 7 patients did not develop any black spots. The treatment period until LG resolution was significantly longer among patients with a black spot than those without a spot (P = .0372). Histologic examination revealed the presence of hemosiderin accumulation accompanied by infiltration of lymphocytes and macrophages in 8 of the 16 patients who had their LGs resected or biopsied. CONCLUSIONS: Accumulation of hemosiderin in the subepithelial layer, together with little blood flow and dense connective tissue in the cartilaginous portion of the vocal fold, are important factors contributing to the persistence of LG.
Eiji Yumoto; Tetsuji Sanuki; Satoru Miyamaru; Yoshihiko Kumai
Related Documents :
8856303 - Hysteroscopy in gestational trophoblastic diseases.
264053 - Discriminant analysis, exemplified with quantitative features of endometrium.
24145293 - Facial scanning with a digital camera: a novel way of screening for primary angle closure.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  118     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-01     Completed Date:  2008-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  932-7     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Honjo, Kumamoto, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Candidiasis / microbiology
Epithelium / metabolism,  pathology
Granuloma / etiology*,  pathology*
Hemorrhage / complications*
Hemosiderin / metabolism
Hyperplasia / metabolism,  pathology
Laryngeal Diseases / etiology*,  microbiology,  pathology*
Lymphocytes / metabolism
Middle Aged
Vocal Cords / metabolism,  microbiology,  pathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ascorbic acid reduces noise-induced nitric oxide production in the guinea pig ear.
Next Document:  Efficacy of nodal dissection for treatment of persistent/recurrent papillary thyroid cancer.