Document Detail

Does storage time influence postthaw survival and pregnancy outcome? An analysis of 11,768 cryopreserved human embryos.
MedLine Citation:
PMID:  19027110     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the impact of cryopreservation storage duration on embryo survival, implantation competence, and pregnancy outcome. DESIGN: Retrospective study. SETTING: Academic tertiary-referral infertility center. PATIENT(S): In vitro fertilization patients and recipients of oocyte donation cycles who had cryopreserved embryos and underwent at least one thaw cycle from 1986 to 2007. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Postthaw survival proportion and implantation, clinical pregnancy, miscarriage, and live birth rates. RESULT(S): Length of storage time did not have a significant effect on postthaw survival for IVF or oocyte donation cycles, or for embryos frozen at the pronuclear or cleavage stages. There was no significant impact of the duration of storage on clinical pregnancy, miscarriage, implantation, or live birth rate, whether from IVF or oocyte donation cycles. Logistic regression analysis demonstrated that the length of storage time or developmental stage at freezing were not predictive of embryo survival or pregnancy outcome. Only oocyte age, survival proportion, and number of transferred embryos were positive predictors of pregnancy outcome. CONCLUSION(S): Cryostorage duration did not adversely affect postthaw survival or pregnancy outcome in IVF or oocyte donation patients.
Ryan Riggs; Jacob Mayer; Donna Dowling-Lacey; Ting-Fing Chi; Estella Jones; Sergio Oehninger
Publication Detail:
Type:  Journal Article     Date:  2008-11-21
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-15     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA.
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MeSH Terms
Abortion, Spontaneous
Embryo Implantation*
Embryo Transfer*
Embryo, Mammalian*
Fertilization in Vitro
Infertility / therapy*
Live Birth
Logistic Models
Odds Ratio
Oocyte Donation
Pregnancy Outcome*
Pregnancy Rate
Reproductive Techniques, Assisted* / adverse effects
Retrospective Studies
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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