Document Detail

Does stenosis severity of native vessels influence bypass graft patency? A prospective fractional flow reserve-guided study.
MedLine Citation:
PMID:  17532405     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: After coronary bypass surgery, occlusion or narrowing of bypass grafts may occur over time. The present study prospectively evaluated the angiographic patency of bypass grafts after 1 year in relation to the preoperative angiographic and functionally severity of the coronary lesion assessed by fractional flow reserve measurement to test the hypothesis that grafting of less critical stenosis may be a risk factor for early dysfunction of the graft. METHODS: The study comprised 164 patients eligible for coronary artery bypass surgery who were not suitable for percutaneous intervention and with at least one intermediate lesion. Fractional flow reserve was measured in all lesions to be grafted to establish if a lesion was functionally significant. The surgeon was blinded to the results of these measurements. One year after surgery, coronary angiography was performed to establish bypass graft patency. RESULTS: At coronary angiography after 1 year, 8.9% of the bypass grafts on functionally significant lesions were occluded, and 21.4% of the bypass grafts on functionally nonsignificant lesions were occluded. There was no difference in angina class or repeat interventions between patients with or without occluded bypass grafts. CONCLUSIONS: The patency of bypass grafts on functionally significant lesions is significantly higher than the patency of bypass grafts on nonsignificant lesions; however, this finding has no clinical relevance because patients with patent or occluded bypass grafts on nonsignificant lesions did not experience an excess of angina or repeat interventions.
Cornelis J Botman; Jacques Schonberger; Sjaak Koolen; Olaf Penn; Hilde Botman; Nabil Dib; Eric Eeckhout; Nico Pijls
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  83     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2093-7     Citation Subset:  AIM; IM    
Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands.
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MeSH Terms
Aged, 80 and over
Blood Pressure
Coronary Angiography
Coronary Artery Bypass / adverse effects*
Coronary Circulation
Coronary Stenosis / surgery*
Graft Occlusion, Vascular / etiology,  radiography*
Middle Aged
Prospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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