| Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock? | |
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MedLine Citation:
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PMID: 16178857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to define the significance of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) upon progression from sepsis or severe sepsis to septic shock a prospective study was designed with 90 enrolled patients with septic syndrome due to ventilator-associated pneumonia. Blood was sampled on seven consecutive days upon initiation of symptoms and concentrations of tumour necrosis factor-alpha (TNFalpha), interleukin-6 (IL-6), IL-8 and sTREM-1 were estimated in serum by an enzymeimmunoassay. No differences in concentrations of TNFalpha, IL-6 and IL-8 were found between patients with sepsis, severe sepsis and septic shock on the first day of presentation of symptoms. Patients presenting with septic shock had concentrations of sTREM-1 significantly higher than both patients with sepsis and severe sepsis on the first day; no difference was found between patients with sepsis and severe sepsis. A positive correlation was detected between sTREM-1 and the white blood cell count. Serum levels of sTREM-1 were significantly lower in patients where VAP resolved compared to those where VAP did not resolve; similar findings were noted between patients who eventually survived and those who died. IL-6 followed the kinetics of sTREM-1 in correlation to patients's prognosis; levels of TNFalpha and IL-8 were unrelated to prognosis. It is concluded that sTREM-1 is particularly increased upon evolution from sepsis or severe sepsis to septic shock. Its sustained increase is an indication of poor outcome. The underlined pathophysiological role of sTREM-1 for the transition from sepsis or severe sepsis to septic shock might constitute a novel target for immunomodulatory therapy. |
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Authors:
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C Routsi; E J Giamarellos-Bourboulis; A Antonopoulou; S Kollias; S Siasiakou; A Koronaios; S Zakynthinos; A Armaganidis; H Giamarellou; C Roussos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 142 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-23 Completed Date: 2005-12-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 62-7 Citation Subset: IM |
Affiliation:
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1st Department of Critical Care, University of Athens Medical School, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease Progression Female Humans Interleukin-6 / blood Interleukin-8 / blood Male Membrane Glycoproteins / immunology* Middle Aged Pneumonia / immunology Prospective Studies Receptors, Immunologic / immunology* Sepsis / blood, immunology Shock, Septic / blood, immunology* Tumor Necrosis Factor-alpha / analysis |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Interleukin-8; 0/Membrane Glycoproteins; 0/Receptors, Immunologic; 0/TREM1 protein, human; 0/Tumor Necrosis Factor-alpha |
| Comments/Corrections | |
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