| Does sodium thiosulphate delay presbyacusis? | |
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MedLine Citation:
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PMID: 20643009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: This study compares the effects of sodium thiosulphate (STS) and normal saline on the prevention of hearing loss. SETTING: Animal research laboratory. METHODS: Sixteen mice were randomized to receive intraperitoneal injections of either normal saline or STS. Auditory brainstem response testing was used to determine baseline and posttreatment hearing thresholds over the course of 1 year. RESULTS: Compared with saline, treatment with STS resulted in a statistically significant improvement in click and pure-tone thresholds until the end of the year. CONCLUSION: STS can significantly delay hearing loss associated with age in this murine model. |
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Authors:
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Taeed Quddusi; Brian W Blakley; Eric Meen; Sylvie Berard; Zameel Dewji |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale Volume: 39 ISSN: 1916-0216 ISO Abbreviation: J Otolaryngol Head Neck Surg Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101479544 Medline TA: J Otolaryngol Head Neck Surg Country: Canada |
Other Details:
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Languages: eng Pagination: 422-5 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, University of Manitoba, Winnipeg, Manitoba. taeed@shaw.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzenesulfonates / administration & dosage, therapeutic use* Disease Models, Animal Dose-Response Relationship, Drug Evoked Potentials, Auditory, Brain Stem / drug effects Hearing / physiology Injections, Intraperitoneal Mice Mice, Inbred C57BL Presbycusis / physiopathology, prevention & control* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Benzenesulfonates; 33305-56-5/thimerfonate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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