Document Detail

Does smokeless tobacco cause hypertension?
MedLine Citation:
PMID:  7597474     Owner:  NLM     Status:  MEDLINE    
This article reviews the literature regarding the cardiovascular effects of smokeless tobacco use. Articles were identified using a MEDLINE search of the English-language literature from 1966 to 1992 and a manual search of bibliographies of identified articles. From 875 articles regarding smokeless tobacco, 12 pertinent articles were identified. Smokeless tobacco caused a clinically significant acute elevation of systolic blood pressure, diastolic blood pressure, or pulse in 5 of 6 experimental trials. Smokeless tobacco was weakly associated with chronic hypertension in 4 of 6 cross-sectional studies. Health care practitioners should be aware that smokeless tobacco may elevate blood pressure up to 90 minutes after use. Smokeless tobacco use should be considered a potential cause of sodium retention and poor blood pressure control because of its nicotine, sodium, and licorice content.
E C Westman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Southern medical journal     Volume:  88     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-01     Completed Date:  1995-08-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  716-20     Citation Subset:  AIM; IM    
Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, NC 27705, USA.
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MeSH Terms
Cross-Sectional Studies
Hypertension / chemically induced*
Nicotine / analysis
Plants, Medicinal
Plants, Toxic*
Sodium / analysis
Tobacco, Smokeless / adverse effects*,  chemistry,  classification
Reg. No./Substance:
54-11-5/Nicotine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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