| Does simultaneous antegrade and retrograde cardioplegia improve functional recovery and myocardial homeostasis? | |
| | |
MedLine Citation:
|
PMID: 11599829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The purpose of our research was to evaluate the functional recovery and homeostasis of myocardium during simultaneous continuous retrograde and antegrade cardioplegia versus continuous retrograde cardioplegia. METHODS: Forty patients who underwent elective coronary artery bypass grafting (CABG) were prospectively assigned to two clinically matched groups and analyzed in respect to cardioplegia protocol. Group I consisted of 24 patients who received continuous retrograde blood cardioplegia; Group II consisted of 16 patients who received simultaneous continuous ante- and retrograde cardioplegia. Hydrogen ion release, carbon dioxide, lactate concentration oxygen content, and oxygen extraction were measured from coronary sinus effluent and from the arterial line before and after cross-clamping of the aorta. Median changes of these parameters were reported. Cardiac output was measured and left and right ventricle stroke works were calculated. Incidence of low cardiac output, ventricular fibrillation, raised cardiac enzymes, and ischemic changes on electrocardiogram (ECG) were noted. RESULTS: In the simultaneous group, oxygen content and oxygen extraction recovered well after cross-clamping. The same parameters did not recover to the same extent in the retrograde group. These changes were notable between groups. Hydrogen ion, carbon dioxide, and lactate releases were comparable between groups. Trend toward better recovery of left ventricle stroke work index was encountered in the simultaneous group. CONCLUSIONS: Viability of myocardium measured with oxygen utilization and functional recovery is better preserved with simultaneous antegrade and retrograde cardioplegia. However, there is no difference in anaerobic metabolism markers. Thus simultaneous ante- and retrograde cardioplegia is probably advantageous over retrograde alone. |
| | |
Authors:
|
M J Jasinski; S Wos; Z Kadziola; I A Wenzel-Jasinska; T J Spyt |
Related Documents
:
|
22583539 - Evaluation of a new pocket echoscopic device for focused-cardiac ultrasonography in eme... 16319049 - Mild hypothermia impairs left ventricular diastolic but not systolic function. 15769709 - Myocardial protection using htk solution in minimally invasive mitral valve surgery. 22560599 - The electrocardiographic diagnosis of intraventricular blocks coexisting with ventricul... 9020339 - The use of hibernation induction triggers for cardiac transplant preservation. 8329419 - Comparison of continuous microperfusion and cold storage for pig heart preservation. 17179019 - Prospective familial assessment in dilated cardiomyopathy: cardiac autoantibodies predi... 145329 - Left ventricular anomalies associated with ebstein's malformation of the tricuspid valve. 15851239 - Late recurrent arrhythmias after ablation of atrial fibrillation: incidence, mechanisms... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of cardiac surgery Volume: 15 ISSN: 0886-0440 ISO Abbreviation: J Card Surg Publication Date: 2000 Sep-Oct |
Date Detail:
|
Created Date: 2001-10-15 Completed Date: 2001-11-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8908809 Medline TA: J Card Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 354-61 Citation Subset: IM |
Affiliation:
|
Department of Cardiothoracic Surgery, Glenfield Hospital, Leicester, United Kingdom. marek.jasinski@glenfield-tr.trent.nhs.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Aorta / surgery Carbon Dioxide / blood Cardiopulmonary Bypass Coronary Artery Bypass Coronary Disease / metabolism*, surgery* Female Heart Arrest, Induced* Hemodynamics / physiology Homeostasis / physiology* Humans Hydrogen-Ion Concentration Lactic Acid / blood Male Middle Aged Myocardium / metabolism* Oxygen / blood Prospective Studies Recovery of Function / physiology* |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Low systemic vascular resistance after cardiopulmonary bypass: incidence, etiology, and clinical imp...
Next Document: Delayed chronic type A dissection following CABG: implications for evolving techniques of revascular...