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Does sildenafil contribute to acute coronary thrombosis?
MedLine Citation:
PMID:  23363902     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Sildenafil was the first oral compound to be approved for the treatment of erectile dysfunction. It is a selective inhibitor of isoform 5 of phosphodiesterase, which is the enzyme responsible for the breakdown of 3', 5'-cyclic guanosine mono-phosphate. Sildenafil-associated myocardial infarction (MI) is rarely seen in patients without previous history of coronary artery disease. A 43-year-old man presented with sudden onset of chest pain. It was determined that his chest pain started after sildenafil intake. Findings consistent with acute anterior MI were observed on electrocardiography. Coronary angiography showed total occlusion of left anterior descending artery with thrombosis. Coronary angioplasty and stenting was successfully performed.
Authors:
Ersan Tatlı; Mehmet Akif Cakar; Emir Doğan; Mustafa Alkan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır     Volume:  40     ISSN:  1016-5169     ISO Abbreviation:  Turk Kardiyol Dern Ars     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2013-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426239     Medline TA:  Turk Kardiyol Dern Ars     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  536-9     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Ada Medical Hospital, Sakarya, Turkey. ersantatli@yahoo.com.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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