Document Detail


Does sex make a difference in survival of patients undergoing resection for early stage non-small cell lung cancer (NSCLC)?
MedLine Citation:
PMID:  19585900     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if sex associated differences exist in presentation and survival of patients undergoing resection for early stage nonsmall cell lung cancer (NSCLC). PATIENTS AND METHODS: Retrospective review of 2207 patients with Surveillance, Epidemiology, and End Results (SEER) Summary Stage I, II or III (local or regional disease) patients eligible for surgery, nonsmall cell lung cancer diagnosed and treated in WV between 1993 and 2000, which underwent surgery as a first course of treatment. Data set obtained from the West Virginia Cancer Registry. RESULTS: 1332 male cases and 875 female cases were reviewed. No statistically significant difference was found with mean age of diagnosis (men 66.5 years; women 67.2 years). A greater proportion of women had adenocarcinoma (p < 0.0001), lower grade (p = 0.002), and lower SEER summary stage (p = 0.009). There was no difference in laterality of tumor, 30-day post surgery survival or surgical procedure between men and women. Regression analysis showed a higher hazard ratio was associated with a increasing stage, grade, and those > or =65 years of age while lower hazard ratio was associated with adenocarcinoma. CONCLUSIONS: This study found that stage, grade, age, and histology, but not sex was the significant prognostic indicators of death in five years.
Authors:
Steven J Jubelirer; Nicole L Varela; Christine A Welch; Mary K Emmett
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The West Virginia medical journal     Volume:  105     ISSN:  0043-3284     ISO Abbreviation:  W V Med J     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-07-09     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413777     Medline TA:  W V Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  18-22     Citation Subset:  IM    
Affiliation:
WVU, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Non-Small-Cell Lung / mortality,  surgery*
Female
Humans
Lung Neoplasms / mortality,  surgery*
Male
Middle Aged
Retrospective Studies
SEER Program
Sex Factors
West Virginia / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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