Document Detail

Does secretin influence rat colonic absorption and secretion?
MedLine Citation:
PMID:  31088     Owner:  NLM     Status:  MEDLINE    
In rats, a secretin (Jorpes) intravenous infusion superimposed on an intracolonic sodium acetate perfusion elicits, with respect to control values, a significant depression of Na+ absorption (0.16 mEq./h-0.00 mEq./h.) and mucus secretion (230-40 mg.). When the hormone is superimposed upon an intracolonic infusion of acetic acid, mucus secretion is also significantly inhibited (790-340 mg.). The influence of secretin on organic anion movement was pH related. At pH values of 7.0, absorption was unchanged (0.34--0.33 mEq./h.), at pH values of 2.9, absorption was significantly reduced (0.67-0.41 mEq./h). The secretin impairment of colonic mucus secretion could influence the transport of watersoluble (Na+) and lipid soluble (acetic acid) substances, probably through changes at the "unstirred layer" level.
L Bustos-Fernandez; I L de Paolo; S Hamamura; E Gonzalez; D Celener; M I Caldarini; O M Tiscornia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  70     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1979-01-24     Completed Date:  1979-01-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  265-9     Citation Subset:  IM    
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MeSH Terms
Acetic Acids
Colon / drug effects,  metabolism*,  secretion
Hydrogen-Ion Concentration
Infusions, Parenteral
Intestinal Absorption / drug effects*
Intestinal Mucosa / drug effects,  metabolism,  secretion*
Mucus / secretion*
Secretin / administration & dosage,  pharmacology,  physiology*
Sodium / metabolism
Reg. No./Substance:
0/Acetic Acids; 1393-25-5/Secretin; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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