| Does a routine operation for intracranial aneurysm incur brain damage? | |
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MedLine Citation:
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PMID: 8561029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A biochemical marker of brain cell damage, the BB-isozyme of the intracellular enzyme Creatine Kinase (CK), was used to evaluate any possible injury to the brain, caused by an operation for a ruptured intracranial aneurysm (SAH). CSF-CK BB was assessed before and at intervals after operation in a series of 60 patients, aged 29-71 (mean 51 years) operated on for intracranial aneurysms, all but one after SAH. The m/f ratio was 18/42. 35 of the 60 patients were operated on acutely, i.e. within 72 hours after the SAH. CK BB was determined as CKB-activity after immunological inactivation of CKM. Normally there should be almost no detectable enzyme activity in the CSF. The pre-operative CK BB-activity was 0.01+ -0.01 mikrokatal in the patients in Hunt & Hess grade I who were operated on > 7 days after their SAH, and 0.05+ -0.04 in those operated on acutely, probably still reflecting the effects of the SAH on the brain. The mean per-operative CK BB increase was 0.11+ -0.17 for patients who had an uneventful postoperative course, compared to 0.39+ -0.49 for those showing some degree of immediate postoperative deterioration. This difference is significant at the 1% level. 52 of the 60 patients showed a rise of CK BB after operation. The mean increase for those patients operated upon in a good state and without any complication or postoperative deterioration was 0.02+ -0.03 mikrokatal, which could therefore be considered as a "normal" or acceptable elevation.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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L Rabow; G Algers; J Elfversson; P A Ridderheim; O Rudolphi; S Zygmunt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurochirurgica Volume: 133 ISSN: 0001-6268 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 1995 |
Date Detail:
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Created Date: 1996-02-26 Completed Date: 1996-02-26 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 13-6 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Norrland University Hospital, Umeå, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aneurysm, Ruptured / enzymology, surgery* Brain Damage, Chronic / diagnosis*, enzymology Creatine Kinase / blood Female Humans Intracranial Aneurysm / enzymology, surgery* Ischemic Attack, Transient / diagnosis, enzymology Isoenzymes Male Middle Aged Neurologic Examination Phosphopyruvate Hydratase / blood Postoperative Complications / diagnosis*, enzymology Risk Factors Subarachnoid Hemorrhage / enzymology, surgery* |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 2.7.3.2/Creatine Kinase; EC 4.2.1.11/Phosphopyruvate Hydratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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