| Does the rodent model adequately predict the effects of ozone induced changes to human erythrocytes? | |
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MedLine Citation:
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PMID: 7412639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is an important need to develop animal models to simulate the response of humans to environmental pollutants. The rodent model has been commonly employed to predict the effects of ambient ozone on human RBCs. The use of rodent models for such a purpose is questioned. This challenge is based on the a) ability of mice to significantly enhance ascorbic acid synthesis following ozone stress, b) the ability of ascorbic acid to prevent oxidant [i.e. acetylphenylhydrazine (APH)] stress to human G-6-PD deficient RBCs and c) the lack of ability of humans to synthesize ascorbic acid. |
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Authors:
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E J Calabrese; G S Moore |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 6 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-11-24 Completed Date: 1980-11-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 505-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascorbic Acid / blood Disease Models, Animal* Erythrocytes / drug effects* Glucosephosphate Dehydrogenase Deficiency / blood Humans Ozone / toxicity* Rats |
| Chemical | |
Reg. No./Substance:
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10028-15-6/Ozone; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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