Document Detail

Does the rodent model adequately predict the effects of ozone induced changes to human erythrocytes?
MedLine Citation:
PMID:  7412639     Owner:  NLM     Status:  MEDLINE    
There is an important need to develop animal models to simulate the response of humans to environmental pollutants. The rodent model has been commonly employed to predict the effects of ambient ozone on human RBCs. The use of rodent models for such a purpose is questioned. This challenge is based on the a) ability of mice to significantly enhance ascorbic acid synthesis following ozone stress, b) the ability of ascorbic acid to prevent oxidant [i.e. acetylphenylhydrazine (APH)] stress to human G-6-PD deficient RBCs and c) the lack of ability of humans to synthesize ascorbic acid.
E J Calabrese; G S Moore
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  6     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-11-24     Completed Date:  1980-11-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  505-7     Citation Subset:  IM    
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MeSH Terms
Ascorbic Acid / blood
Disease Models, Animal*
Erythrocytes / drug effects*
Glucosephosphate Dehydrogenase Deficiency / blood
Ozone / toxicity*
Reg. No./Substance:
10028-15-6/Ozone; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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