Document Detail


Does risk for anxiety increase during the menopausal transition? Study of women's health across the nation.
MedLine Citation:
PMID:  23615639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Little is known about the risk of anxiety in women during midlife and the menopausal transition. We examined anxiety as a cluster of four symptoms and determined the association between menopausal stage and high anxiety during 10 years of follow-up of 2,956 women of multiple race/ethnicities.
METHODS: This study was a longitudinal analysis of data from the multisite Study of Women's Health Across the Nation, a study of menopause and aging. Women were aged 42 to 52 at study entry. The outcome was high anxiety, with a score of 4 or greater on the sum of four anxiety symptoms rated according to frequency in the previous 2 weeks from 0 (none) to 4 (daily; upper 20%). Covariates included sociodemographics, health factors, stressors, and vasomotor symptoms.
RESULTS: Women with low anxiety at baseline were more likely to report high-anxiety symptoms at early or late perimenopause or postmenopause than at premenopause (odds ratio, 1.56-1.61), independent of multiple risk factors, including upsetting life events, financial strain, fair/poor perceived health, and vasomotor symptoms. Women with high anxiety at baseline continued to have high rates of high anxiety throughout follow-up, but odds ratios did not differ by menopausal stage.
CONCLUSIONS: Women with high anxiety at premenopause may be more often anxious and are not at increased risk for high anxiety at specific stages of the menopausal transition. In contrast, women with low anxiety at premenopause may be more susceptible to high anxiety during and after the menopausal transition than before the menopausal transition.
Authors:
Joyce T Bromberger; Howard M Kravitz; Yuefang Chang; John F Randolph; Nancy E Avis; Ellen B Gold; Karen A Matthews
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  20     ISSN:  1530-0374     ISO Abbreviation:  Menopause     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2014-01-06     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  488-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anxiety / epidemiology*,  psychology
Fear
Female
Humans
Irritable Mood
Longitudinal Studies
Middle Aged
Perimenopause / psychology*
Postmenopause / psychology*
Premenopause / psychology*
Prevalence
Risk Factors
Severity of Illness Index
United States / epidemiology
Grant Support
ID/Acronym/Agency:
AG012495/AG/NIA NIH HHS; AG012505/AG/NIA NIH HHS; AG012531/AG/NIA NIH HHS; AG012535/AG/NIA NIH HHS; AG012539/AG/NIA NIH HHS; AG012546/AG/NIA NIH HHS; AG012553/AG/NIA NIH HHS; AG012554/AG/NIA NIH HHS; NR004061/NR/NINR NIH HHS; R01 MH059689/MH/NIMH NIH HHS
Comments/Corrections
Comment In:
Menopause. 2013 May;20(5):481-2   [PMID:  23615637 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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