Document Detail

Does repeated and heavy exercise impair blood rheology in carriers of sickle cell trait?
MedLine Citation:
PMID:  17993789     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if the time courses of hemorheologic parameters are different between carriers of sickle cell trait (SCT) and subjects with normal hemoglobin in response to exercise. DESIGN: Observational and comparative study. SETTING: Testing was conducted in a laboratory of exercise physiology. PARTICIPANTS: Nine carriers of sickle cell trait (SCT group) and 7 subjects with normal hemoglobin (CONT group) performed an exercise protocol of the repetition of 3 successive maximal ramp exercise tests. INTERVENTIONS: Blood was sampled at rest (TR), at the end of each of the 3 tests (T1, T2, T3), and during the immediate (T2h) and late (T24h, T48h) recovery periods. MAIN OUTCOME MEASUREMENTS: Blood and plasma viscosity (etab and etap, respectively), hematocrit (Hct), and red blood cell (RBC) rigidity (Tk and k indexes) were determined. RESULTS: In both groups, etab significantly increased in response to exercise but the SCT group had significantly higher etab at T3 and T2h. etab then returned to baseline value at T2h in the CONT group and at T24h in the SCT group. Tk and k were not changed by exercise but significantly increased above baseline value in both groups at T24h and T48h. The increase in Tk and k during late recovery was higher in the SCT group than in the CONT group, indicating that SCT carriers had significantly higher RBC rigidity than the CONT group at that time. CONCLUSIONS: The hemorheologic changes induced by exercise in the SCT carriers could trigger microcirculatory disorders during the recovery.
Julien Tripette; Marie-Dominique Hardy-Dessources; Fagnété Sara; Mona Montout-Hedreville; Christian Saint-Martin; Olivier Hue; Philippe Connes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine     Volume:  17     ISSN:  1050-642X     ISO Abbreviation:  Clin J Sport Med     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-02-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9103300     Medline TA:  Clin J Sport Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-70     Citation Subset:  IM    
Université des Antilles et de la Guyane, Laboratoire ACTES (EA 3596), Département de Physiologie, Campus de Fouillole, Guadeloupe, French West Indies.
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MeSH Terms
Erythrocytes / physiology*
Exercise / physiology*
Exercise Test
Monitoring, Physiologic / methods
Physical Exertion / physiology*
Sickle Cell Trait / physiopathology*

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