Document Detail

Does the renin-angiotensin system also regulate intra-ocular pressure?
MedLine Citation:
PMID:  18608133     Owner:  NLM     Status:  Publisher    
The renin-angiotensin-aldosterone system is known to play an essential role in controlling sodium balance and body fluid volumes, and thus blood pressure. In addition to the circulating system which regulates urgent cardiovascular responses, a tissue-localized renin-angiotensin system (RAS) regulates long-term changes in various organs. Many recognized RAS components have also been identified in the human eye. The highly vasoconstrictive angiotensin II (Ang II) is considered the key peptide in the circulatory RAS. However, the ultimate effect of RAS activation at tissue level is more complex, being based not only on the biological activity of Ang II but also on the activities of other products of angiotensinogen metabolism, often exerting opposite effects to Ang II action. In recent studies, orally administered angiotensin II type 1 receptor blockers and angiotensin-converting enzyme inhibitors lower intra-ocular pressure (IOP), likewise topical application of these compounds, the effect being more prominent in ocular hypertensive eyes. Based on previous findings and our own experimental data, it can strongly be suggested that the RAS not only regulates blood pressure but is also involved in the regulation of IOP.
Anu Vaajanen; Satu Luhtala; Olli Oksala; Heikki Vapaatalo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2008-4-10
Journal Detail:
Title:  Annals of medicine     Volume:  -     ISSN:  1365-2060     ISO Abbreviation:  Ann. Med.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-7-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-10     Citation Subset:  -    
Institute of Biomedicine, Pharmacology, University of Helsinki, Finland.
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