Document Detail

Does a relationship exist between the urate pool in the body and lipid peroxidation during exercise?
MedLine Citation:
PMID:  10625215     Owner:  NLM     Status:  MEDLINE    
In this study, we investigated whether a relationship exists between the levels of urate in vivo and lipid peroxidation during exercise. Seven healthy male subjects performed exhaustive cycling exercise under the following three conditions. The levels of urate, thiobarbituric acid reactive substances (TBARS) and allantoin in plasma and urine were examined before exercise and during a 3h recovery period. (1) Benzbromarone administration experiment: benzbromarone (an uricosuric agent) was administered orally the day before exercise. (2) IMP administration experiment: inosine 5'-monophosphate disodium salt (a precursor of urate) was administered orally the day before exercise. (3) Control experiment: no test substance was administered. The main results obtained were as follows. Plasma urate levels and total peroxyl radical-trapping antioxidant parameter (TRAP) for deproteinized plasma in the resting period significantly decreased depending on the treatment, in the order of IMP> control > benzbromarone. A significant positive correlation was evident between plasma urate levels and TRAP values for deproteinized plasma. The increase in plasma levels of allantoin was observed only in the case of IMP treatment. A significant negative correlation between plasma levels of urate in the resting period and the amounts of urinary TBARS excreted during the recovery period was recognized. These results suggest that the urate level in vivo before exercise is a factor influencing lipid peroxidation during exhaustive exercise. Furthermore, these findings support the view that urate may serve as an important freeradical scavenger in vivo.
T Mikami; Y Yoshino; A Ito
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  32     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-18     Completed Date:  2000-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  IM    
Department of Health and Sports Science, Nippon Medical School, Kawasaki, Kanagawa, Japan.
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MeSH Terms
Allantoin / blood
Ascorbic Acid / metabolism
Benzbromarone / pharmacology
Case-Control Studies
Exercise / physiology*
Inosine Monophosphate / pharmacology
Lactates / blood
Lipid Peroxidation / drug effects,  physiology*
Oxidative Stress
Thiobarbituric Acid Reactive Substances / metabolism
Uric Acid / blood*,  urine*
Uricosuric Agents / pharmacology
Vitamin E / blood
Reg. No./Substance:
0/Lactates; 0/Thiobarbituric Acid Reactive Substances; 0/Uricosuric Agents; 131-99-7/Inosine Monophosphate; 1406-18-4/Vitamin E; 3562-84-3/Benzbromarone; 50-81-7/Ascorbic Acid; 69-93-2/Uric Acid; 97-59-6/Allantoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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