Document Detail

Does the reduction in systolic blood pressure alone explain the regression of left ventricular hypertrophy?
MedLine Citation:
PMID:  15592569     Owner:  NLM     Status:  MEDLINE    
Systolic blood pressure (SBP) is an important determinant of the development and regression of left ventricular hypertrophy (LVH) in hypertensive humans. However, comparative assessments with other BP components are scarce and generally limited in size. As part of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA), 743 hypertensive subjects underwent echocardiography and 24-h ambulatory BP monitoring before and after an average of 3.9 years of treatment. The changes in left ventricular mass showed a significant direct association with the changes in 24-h SBP (r=0.40), diastolic blood pressure (DBP) (r=0.33) and pulse pressure (PP) (r=0.35). Weaker associations were found with the changes in clinic BP (r=0.32, 0.31 and 0.16, respectively). In a multivariate linear regression analysis, the changes in 24-h SBP were the sole independent determinants of the changes in left ventricular mass (LVM) according to the following equation: percentage changes in LVM=0.73 x (percentage changes in 24-h SBP) -0.48 (P<0.0001). For any given reduction in 24-h SBP, the reduction in LVM did not show any association with the changes in DBP and PP, either clinic or ambulatory. These data indicate that SBP is the principal determinant of LVH regression in hypertensive humans.
P Verdecchia; F Angeli; R Gattobigio; M Guerrieri; G Benemio; C Porcellati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  18 Suppl 2     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  S23-8     Citation Subset:  IM    
Department of Cardiovascular Disease, Hospital R. Silvestrini, Perugia, Italy.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Follow-Up Studies
Hypertension / complications,  drug therapy*,  physiopathology
Hypertrophy, Left Ventricular / drug therapy*,  etiology,  physiopathology
Linear Models
Middle Aged
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents

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