Document Detail

Does reduction of blood prolactin levels reveal the activation of central dopaminergic pathways conveying reward in top athletes?
MedLine Citation:
PMID:  12781656     Owner:  NLM     Status:  MEDLINE    
Prolactin blood levels are modulated directly by CNS via the known tubero-infundibular dopaminergic neurons which exert an inhibitory action on lactotrope cells in the hypophysis. Prolactin is devoid of peripheral negative feedback and via lesser known central pathways (e.g., mesolimbic and mesocortical) might be further tuned by means of appropriate stimuli (e.g., addictive drugs, gambling, exercise and so forth). Therefore, a prolactin test can be utilised to obtain an objective index to assess the compliance to exercise in men. This index may be used to identify the most suitable athlete for a given sport and mainly to survey exercise as rewarding behaviour in trained people. Prolactin was assessed in male top world windsurfers (WS) and in a control group of non-windsurfer trained subjects (CS) during an exercise simulating marine windsurfing. The result was that prolactin levels decreased significantly in WS with respect to CS when compared with pre-test levels (WS: -22.7%; P<0.05).
F Melis; A Crisafulli; A Rocchitta; F Tocco; A Concu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  61     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-03     Completed Date:  2004-03-10     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  133-5     Citation Subset:  IM    
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MeSH Terms
Dopamine / physiology*
Neurons / physiology*
Physical Education and Training
Prolactin / blood*
Time Factors
Reg. No./Substance:
9002-62-4/Prolactin; VTD58H1Z2X/Dopamine

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