Document Detail

Does reducing the rate or efficiency of digestion reduce food intake?
MedLine Citation:
PMID:  1415798     Owner:  NLM     Status:  MEDLINE    
Two strains of rats (Charles River CD and Lewis) were fed high-moisture (71% water) diets containing 50-300 mg acarbose/kg dry diet for 1-3 wk. Acarbose impaired carbohydrate digestion in both strains, as evidenced by increased fecal excretion and increased intestinal contents. For both strains the highest dose of acarbose tended to stimulate food intake, whereas an intermediate dose (100 mg/kg) inhibited food intake. The lowest dose (50 mg/kg) had no significant effect. In general the food intake-promoting effect of acarbose was more pronounced in CD rats, whereas the food intake-inhibiting effect of acarbose was more pronounced in Lewis rats. To determine whether increased intestinal bulk, due to undigested food, was responsible for the reduced food intake, another experiment was conducted in which Lewis rats were fed diets containing 5-25% cellulose. Although this level of cellulose should have increased fecal bulk to the same degree as acarbose, cellulose increased rather than decreased food intake. It is proposed that the presence of incompletely digested food in the digestive tract can inhibit food intake for several days. Because manipulating diet moisture altered energy intake without altering percentage of food excreted as feces, it is proposed that acarbose and diet moisture alter food intake by different mechanisms.
I Ramirez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  263     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-19     Completed Date:  1992-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R852-6     Citation Subset:  IM    
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104-3308.
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MeSH Terms
Animal Feed
Defecation / drug effects
Digestion / physiology*
Eating* / drug effects
Gastrointestinal Contents / drug effects
Rats, Inbred Lew
Rats, Inbred Strains
Time Factors
Trisaccharides / pharmacology
Weight Gain / drug effects
Grant Support
Reg. No./Substance:
0/Trisaccharides; 56180-94-0/Acarbose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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