Document Detail

Does reduced erythrocyte C3b receptor (CR1) activity contribute to the pathogenesis of yersinia triggered reactive arthritis?
MedLine Citation:
PMID:  1531747     Owner:  NLM     Status:  MEDLINE    
Erythrocyte C3b receptor (CR1) activity was measured in 27 patients with yersinia triggered reactive arthritis and in 151 control subjects, including 36 patients with uncomplicated yersiniosis and 115 healthy subjects. CR1 was measured by the immune adherence haemagglutination method. Patients with yersinia triggered reactive arthritis had reduced levels of CR1 compared with the controls. This difference was mainly due to the finding that five out of six HLA B27 negative patients with arthritis had decreased CR1 activity. Such a quantitative difference may contribute to the pathogenesis of reactive arthritis by affecting the clearance of immune complexes.
R Lahesmaa; E Eerola; A Toivanen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  51     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  97-100     Citation Subset:  IM    
Department of Medical Microbiology, Turku University, Finland.
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MeSH Terms
Arthritis, Infectious / etiology,  immunology*
Erythrocytes / immunology*
HLA-B27 Antigen / analysis
Immune Adherence Reaction
Receptors, Complement / analysis*
Receptors, Complement 3b
Yersinia Infections / immunology*
Reg. No./Substance:
0/HLA-B27 Antigen; 0/Receptors, Complement; 0/Receptors, Complement 3b

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