| Does reactivity to stress cosegregate with subclinical psychosis? A general population twin study. | |
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MedLine Citation:
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PMID: 18822092 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study assessed the relationship between stress reactivity (trait 1) and psychosis (trait 2) across genetically related persons (cross-twin, cross-trait design) to examine whether stress reactivity is an uncontaminated and unconfounded familial marker of psychosis risk. METHOD: Reactivity to stress and subclinical psychotic experiences were assessed in 289 female, general population twin-pairs. Cross-trait, within-twin associations investigating the association between stress reactivity and subclinical psychotic experiences in each person, were calculated. In addition, cross-trait, cross-twin associations were calculated to assess whether stress reactivity in one twin was moderated by subclinical psychotic experiences in the co-twin. RESULTS: Cross-trait, within-twin analyses showed significant associations between stress reactivity and subclinical psychotic experiences in each person. In addition, the cross-trait cross-twin analyses showed that stress reactivity in twin 1 was significantly moderated by subclinical experiences in the co-twin. CONCLUSION: The results suggest that the psychosis phenotype cosegregates with increased emotional reactivity to stress in daily life. |
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Authors:
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T Lataster; M Wichers; N Jacobs; R Mengelers; C Derom; E Thiery; J Van Os; I Myin-Germeys |
Publication Detail:
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Type: Journal Article; Twin Study Date: 2008-09-19 |
Journal Detail:
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Title: Acta psychiatrica Scandinavica Volume: 119 ISSN: 1600-0447 ISO Abbreviation: Acta Psychiatr Scand Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-12 Completed Date: 2009-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370364 Medline TA: Acta Psychiatr Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 45-53 Citation Subset: IM |
Affiliation:
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Maastricht University-Psychiatry and Neuropsychology, Maastricht 6200MD, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arousal / genetics* Cross-Sectional Studies Diseases in Twins / diagnosis, genetics*, psychology Emotions Female Genetic Predisposition to Disease Genotype Humans Middle Aged Netherlands Phenotype Psychotic Disorders / diagnosis, genetics*, psychology Social Environment Stress, Psychological / complications* Twins, Dizygotic / genetics, psychology Twins, Monozygotic / genetics, psychology Young Adult |
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