Document Detail


Does the rate of fat deposition influence the pharmacokinetic disposition of subcutaneously administered moxidectin and ivermectin in pigs?
MedLine Citation:
PMID:  12423225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Body condition has been shown to affect the pharmacokinetics of subcutaneously administered macrocyclic lactone anthelmintics but the underlying mechanism is unknown. This study examined the effect of different rates of fat deposition on the pharmacokinetics of moxidectin (MXD) and ivermectin (IVM). All animals initially received a diet with a high linoleic acid content for 7 weeks. One group of animals then received a normal grower diet while the other half received a maintenance ration. Within each diet group, animals were treated with either IVM (n = 4) or MXD (n = 4) or remained as untreated controls (n = 2). There was no difference in the proportion of linoleic acid between the drug treated groups and the untreated controls at any time throughout the study. At 4 and 9 weeks after treatment there was a significantly lower proportion of linoleic acid in the pigs fed the normal ration indicating a greater fat deposition in these animals compared with those that received the maintenance diet. There was an increased persistence of MXD in the plasma of pigs fed the normal ration compared with those fed the maintenance ration. No differences were seen in the kinetic disposition of IVM between pigs fed the maintenance or normal ration. Reducing the rate of fat deposition influenced the pharmacokinetic disposition of the highly lipophilic MXD but did not influence the pharmacokinetic disposition of the less lipophilic IVM.
Authors:
J Craven; D R Hennessy; C Friis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  25     ISSN:  0140-7783     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-08     Completed Date:  2003-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-7     Citation Subset:  IM    
Affiliation:
Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, Dyrlaegevej 100, DK-1870 Frederiksberg C, Denmark. jcr@kvl.dk
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Animals
Anti-Bacterial Agents / administration & dosage,  blood,  pharmacokinetics*
Area Under Curve
Chromatography, Liquid / veterinary
Diet
Female
Injections, Subcutaneous / veterinary
Ivermectin / administration & dosage,  blood,  pharmacokinetics*
Linoleic Acid / metabolism*
Macrolides
Male
Swine / metabolism*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Macrolides; 2197-37-7/Linoleic Acid; 51570-36-6/milbemycin; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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