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Does radioiodine therapy in patients with differentiated thyroid cancer increase the frequency of another malignant neoplasm?
MedLine Citation:
PMID:  22084737     Owner:  NLM     Status:  In-Data-Review    
Objectives. To compare the frequency of another primary malignancy in patients with differentiated thyroid carcinoma (DTC) who received radioiodine therapy or not ((131)I). Material and Methods. 168 cases of DTC patients were retrospectively evaluated as to the frequency of another neoplasia by comparing patients with and without it, taking into account clinical, laboratory, and therapeutic parameters. Results. Another primary malignancy occurred in 8.9% of patients. Of these, 53.3% showed the malignancy before (131)I and 46.7% after it. By comparing both groups, the age at the moment of diagnosis of another neoplasia was 46.1 ± 20.2 years for the group before (131)I therapy and of 69.4 ± 11.4 years for the group after it (P = 0.02). Of the 148 patients treated with (131)I, 4.7% developed another malignancy. The latter were older (61 ± 17 years) than those who did not show another cancer type (44.1 ± 14.2 years) (P < 0.05). Conclusion. The frequency of another neoplasia found after (131)I was similar to that found before (131)I.
Renata Midori Hirosawa; Monica Marivo; Juliana de Moura Leite Luengo; Jose Vicente Tagliarini; Emanuel Cellice Castilho; Mariangela de Alencar Marques; Yoshio Kiy; Marilia Martins Silveira Marone; Liciana Vaz de Arruda Silveira; Glaucia Maria Ferreira da Silva Mazeto
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Publication Detail:
Type:  Journal Article     Date:  2011-08-14
Journal Detail:
Title:  ISRN oncology     Volume:  2011     ISSN:  2090-567X     ISO Abbreviation:  ISRN Oncol     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101567026     Medline TA:  ISRN Oncol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  708343     Citation Subset:  -    
Departamento de Clinica Medica, Faculdade de Medicina (FMB), UNESP, Rubiao Junior s/n, Botucatu, 18618-000 São Paulo, Brazil.
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