| Does on-pump normothermic beating-heart valve surgery with low tidal volume ventilation protect the lungs? | |
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MedLine Citation:
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PMID: 21997651 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Postoperative pulmonary dysfunction following cardiopulmonary bypass (CPB) usually develops secondary to the inflammatory process with contact activation, hypothermia, operative trauma, general anesthesia, atelectasis, pain, and pulmonary ischemia/reperfusion due to crossclamping. The aim of the present study was to evaluate the effects of an on-pump, normothermic, and beating-heart technique and of low-volume ventilation on lung injury.Methods: We compared the results for 20 patients who underwent operations with an on-pump, normothermic, and beating-heart technique of mitral valve surgery with low-volume ventilation (group 1) with the results for 23 patients who underwent their operations with an on-pump, hypothermic cardiacarrest technique (group 2). In both groups, blood samples were collected from the right superior pulmonary vein, and inflammation and oxidative stress markers (malondialdehyde, lactic acid, platelet-activating factor, and myeloperoxidase) were studied.Results: Malondialdehyde, myeloperoxidase, and lactate values were significantly lower in group 1 than in group 2 just before the termination of CPB (P < .05). We observed no differences between the 2 groups with regard to values for platelet-activating factor.Conclusions: Inflammation and oxidative stress markers were lower in the group of patients who underwent beating-heart valve surgery with low-volume ventilation. These results reflect less of an ischemic insult and lower inflammation compared with the results for the patients who underwent conventional operations. |
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Authors:
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Ufuk Tütün; Ali Ihsan Parlar; Levent Altinay; Deniz Ilhan Topcu; Seyhan Babaroglu; Kerem Yay; Ufuk Mungan; Ferit Cicekcioglu; Gul Sevim Saydam; Salih Fehmi Katircioglu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The heart surgery forum Volume: 14 ISSN: 1522-6662 ISO Abbreviation: Heart Surg Forum Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100891112 Medline TA: Heart Surg Forum Country: United States |
Other Details:
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Languages: eng Pagination: E297-301 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Türkiye Yüksek htisas E itim ve Ara tırma, Hastanesi, Ankara. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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