Document Detail

Does on-pump normothermic beating-heart valve surgery with low tidal volume ventilation protect the lungs?
MedLine Citation:
PMID:  21997651     Owner:  NLM     Status:  In-Data-Review    
Background: Postoperative pulmonary dysfunction following cardiopulmonary bypass (CPB) usually develops secondary to the inflammatory process with contact activation, hypothermia, operative trauma, general anesthesia, atelectasis, pain, and pulmonary ischemia/reperfusion due to crossclamping. The aim of the present study was to evaluate the effects of an on-pump, normothermic, and beating-heart technique and of low-volume ventilation on lung injury.Methods: We compared the results for 20 patients who underwent operations with an on-pump, normothermic, and beating-heart technique of mitral valve surgery with low-volume ventilation (group 1) with the results for 23 patients who underwent their operations with an on-pump, hypothermic cardiacarrest technique (group 2). In both groups, blood samples were collected from the right superior pulmonary vein, and inflammation and oxidative stress markers (malondialdehyde, lactic acid, platelet-activating factor, and myeloperoxidase) were studied.Results: Malondialdehyde, myeloperoxidase, and lactate values were significantly lower in group 1 than in group 2 just before the termination of CPB (P < .05). We observed no differences between the 2 groups with regard to values for platelet-activating factor.Conclusions: Inflammation and oxidative stress markers were lower in the group of patients who underwent beating-heart valve surgery with low-volume ventilation. These results reflect less of an ischemic insult and lower inflammation compared with the results for the patients who underwent conventional operations.
Ufuk Tütün; Ali Ihsan Parlar; Levent Altinay; Deniz Ilhan Topcu; Seyhan Babaroglu; Kerem Yay; Ufuk Mungan; Ferit Cicekcioglu; Gul Sevim Saydam; Salih Fehmi Katircioglu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The heart surgery forum     Volume:  14     ISSN:  1522-6662     ISO Abbreviation:  Heart Surg Forum     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100891112     Medline TA:  Heart Surg Forum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E297-301     Citation Subset:  IM    
Department of Cardiovascular Surgery, Türkiye Yüksek htisas E itim ve Ara tırma, Hastanesi, Ankara.
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