Document Detail


Does prior infertility increase the risk of tubal pregnancy?
MedLine Citation:
PMID:  3595915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One hundred forty-nine patients who underwent surgery for tubal pregnancy at five hospitals in Seattle (WA) between 1975 and 1979 were interviewed to determine the risk factors for this disorder. Their responses were compared with those of 706 control women who had conceived an intrauterine pregnancy during the same time period during which the tubal pregnancies occurred. A higher proportion of cases reported a history of infertility (attempt to conceive without success for a period of at least 1 year) than controls (relative risk [RR] = 2.5; 95% confidence interval [CI] = 1.7-3.7). Women who were diagnosed in the investigation of their infertility as having tubal or ovulatory dysfunction had relative risks of tubal pregnancy of 5.8 (95% CI = 2.1-16.4) and 3.4 (95% CI = 1.3-8.5), respectively. The average time over which subjects had attempted to conceive before index pregnancies that were planned was longer among cases (15.4 months) than among controls (6.9 months). These results support the hypothesis that a history of infertility predisposes women to an increased risk of tubal pregnancy. The authors also found that, among infertile women, about twice as many cases (14.3%) as controls (6.8%) were current fertility drug users (RR = 3.1; 95% CI = 1.1-9.1), which suggests that the use of fertility drug(s) may further increase the risk of tubal pregnancy.
Authors:
C P Yang; W H Chow; J R Daling; N S Weiss; D E Moore
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Fertility and sterility     Volume:  48     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-08-07     Completed Date:  1987-08-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  62-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fertility Agents, Female / toxicity
Humans
Infertility, Female / complications*
Pregnancy
Pregnancy, Tubal / etiology*
Risk
Time Factors
Grant Support
ID/Acronym/Agency:
1 N01 HD 02821/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Fertility Agents, Female

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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