Document Detail


Does the presence of nuclear vacuoles in human sperm selected for ICSI affect pregnancy outcome?
MedLine Citation:
PMID:  16497697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To verify whether or not microinjection of sperm with a normal nuclear shape but large vacuoles affects IVF-ICSI pregnancy outcome. METHODS: A comparative study testing IVF outcome parameters of IVF-ICSI, based on morphological selection of spermatozoa with normal nuclei against those based on microinjection of sperm with a normal nuclear shape but large vacuoles. An experimental group, including 28 IVF-ICSI cycles, where only embryos obtained from microinjection of spermatozoa with a normal nuclear shape but large vacuoles were transferred, was matched with a control group, including 28 IVF-ICSI cycles, where only embryos obtained from microinjection of spermatozoa with a strictly defined morphologically normal nuclear shape and content were transferred. The main outcome was IVF-ICSI pregnancy rate. RESULTS: The experimental group exhibited a significantly lower pregnancy rate per cycle and significantly higher abortion rate per pregnancy compared to the control group (18 versus 50%, and 80 versus 7%, respectively, P=0.01). CONCLUSION: Microinjection of vacuolated sperm appears to reduce the pregnancy rate and appears to be associated with early abortion.
Authors:
Arie Berkovitz; Fina Eltes; Adrian Ellenbogen; Sigal Peer; Dov Feldberg; Benjamin Bartoov
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Publication Detail:
Type:  Journal Article     Date:  2006-02-23
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  21     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-04     Completed Date:  2006-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1787-90     Citation Subset:  IM    
Affiliation:
IVF Unit, Department of Obstetrics and Gynaecology, Sapir Medical Center, Meir Hospital, Kfar Saba, and Male Fertility Laboratory, Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Male
Pregnancy
Pregnancy Outcome*
Retrospective Studies
Sperm Injections, Intracytoplasmic*
Sperm Motility
Spermatozoa / ultrastructure*
Vacuoles / ultrastructure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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