| Does preoperative treatment with a gonadotropin-releasing hormone agonist improve the outcome of endometrial resection? | |
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MedLine Citation:
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PMID: 9782138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: To verify if more favorable long-term results of endometrial resection can be obtained with preoperative gonadotropin-releasing hormone (GnRH) agonist treatment. DESIGN: Multicenter, randomized, controlled trial (Canadian Task Force classification I). SETTING: Tertiary care academic department. PATIENTS: Sixty-three premenopausal women with established menorrhagia. INTERVENTION: Eight weeks of goserelin depot treatment before endometrial resection or immediate surgery in the early proliferative phase of the cycle. MEASUREMENTS AND MAIN RESULTS: Variations in menstrual patterns and bleeding scores as well as overall degree of satisfaction with treatment were determined 1 year after endometrial resection. Mean +/- SD monthly pictorial blood loss-assessment chart scores in the second 6-month follow-up period were 26.9 +/- 31.6 in the goserelin group and 44.0 +/- 45.7 in the immediate surgery group (mean difference 17.1 points, 95% CI -3.0 to +37.2, p = 0.09, unpaired t test). Respective amenorrhea rates were 34% (11/32) and 20% (6/20, p = 0.26, Fisher's exact test, 95% CI of difference -8% to +37%). Overall satisfaction with treatment was 91% and 87%, respectively. CONCLUSION: Administration of a GnRH agonist before endometrial resection is advantageous for surgery, but has a limited effect in terms of postoperative bleeding pattern and appears not to offer clear-cut long-term clinical benefit. |
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Authors:
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P Vercellin; A Perin; R Consonn; S Oldan; F Parazzini; P G Crosignani |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of the American Association of Gynecologic Laparoscopists Volume: 5 ISSN: 1074-3804 ISO Abbreviation: J Am Assoc Gynecol Laparosc Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-01-29 Completed Date: 1999-01-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9417443 Medline TA: J Am Assoc Gynecol Laparosc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 357-60 Citation Subset: IM |
Affiliation:
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Clinica Ostetrica e Ginecologica "Luigi Mangiagalli," Universita di Milano, Via Commenda, 12, 20122 Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenomyoma
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complications,
surgery Adult Antineoplastic Agents, Hormonal / administration & dosage, therapeutic use* Delayed-Action Preparations Electrocoagulation* / methods Endometrium / surgery* Endoscopy* Female Goserelin / administration & dosage, therapeutic use* Humans Menorrhagia / drug therapy, etiology, surgery* Middle Aged Preoperative Care Prospective Studies Treatment Outcome Uterine Neoplasms / complications, surgery |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Hormonal; 0/Delayed-Action Preparations; 65807-02-5/Goserelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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