| Does preoperative rofecoxib (Vioxx) decrease postoperative pain with laparoscopic cholecystectomy? | |
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MedLine Citation:
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PMID: 15450833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A prospective, randomized, double-blinded clinical trial was designed to study the effects of preemptive rofecoxib (Vioxx) analgesia in patients undergoing elective laparoscopic cholecystectomy. METHODS: One hundred-twenty patients were enrolled in the study over a 21-month period, and 116 completed the study. One half of the patients received 50 mg rofecoxib preoperatively and the other half, placebo. Both groups were demographically similar. Medical information, patient and nursing assessments, and surgical data were evaluated. RESULTS: A significant reduction in requirements for postoperative narcotic analgesic dosing was noted in the rofecoxib group. In addition, patients receiving rofecoxib reported significantly less nausea and improvement in their activity level when compared with the control group. No complications were encountered with the preoperative use of rofecoxib. CONCLUSIONS: We conclude that in patients undergoing laparoscopic cholecystectomy, preoperative administration of rofecoxib in selected patients may facilitate postoperative recovery and decrease postoperative narcotic requirements. |
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Authors:
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Mark C Horattas; Steve Evans; Kimberly D Sloan-Stakleff; Christopher Lee; Joseph W Snoke |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of surgery Volume: 188 ISSN: 0002-9610 ISO Abbreviation: Am. J. Surg. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-28 Completed Date: 2004-10-27 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 271-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2004 Excerpta Medica, Inc. |
Affiliation:
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Department of Surgery, Akron General Medical Center, Northeastern Ohio Universities College of Medicine, 400 Wabash Ave., Akron, OH 44307, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents, Non-Steroidal / administration & dosage* Cholecystectomy, Laparoscopic / adverse effects* Double-Blind Method Female Humans Lactones / administration & dosage* Male Middle Aged Pain, Postoperative / drug therapy, etiology, prevention & control* Preoperative Care Prospective Studies Sulfones Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Lactones; 0/Sulfones; 0/rofecoxib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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