Document Detail

Does prenatal influenza divert susceptible females from later affective psychosis to schizophrenia?
MedLine Citation:
PMID:  8296576     Owner:  NLM     Status:  MEDLINE    
We examined the relationship between influenza epidemics and the number of schizophrenic and affective psychotic individuals born each month between 1938 and 1965 in England and Wales. Increased death rates from influenza were followed 5 months later by a significant increase in schizophrenic births and a concurrent fall in the number of births of affective psychotic individuals. When the sexes were examined separately, both the positive effect of influenza on schizophrenic births and its negative effect on affective psychotic births were evident for females but not for males. Furthermore, during February to June in high influenza years, there was an inverse relationship between the number of female schizophrenic and affective psychotic births. The explanation for these surprising findings may be that prenatal exposure to influenza impairs the neurodevelopment of some females with a predisposition to affective psychosis, in such a way that their later illness shows schizophrenic rather than affective features.
N Takei; E O'Callaghan; P C Sham; G Glover; R M Murray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  88     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-25     Completed Date:  1994-02-25     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  328-36     Citation Subset:  IM    
Department of Psychological Medicine, Institute of Psychiatry, London, United, Kingdom.
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MeSH Terms
Affective Disorders, Psychotic / epidemiology*,  etiology
Cross-Sectional Studies
Delirium, Dementia, Amnestic, Cognitive Disorders / epidemiology*,  etiology
Disease Outbreaks*
England / epidemiology
Infant, Newborn
Influenza, Human / complications,  epidemiology*
Middle Aged
Poisson Distribution
Prenatal Exposure Delayed Effects*
Risk Factors
Schizophrenia / epidemiology*,  etiology
Schizophrenic Psychology*
Sex Factors
Wales / epidemiology
Grant Support
//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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