Document Detail

Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?
MedLine Citation:
PMID:  7488569     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.
D Cotter; N Takei; M Farrell; P Sham; P Quinn; C Larkin; J Oxford; R M Murray; E O'Callaghan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Schizophrenia research     Volume:  16     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-03     Completed Date:  1996-01-03     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  233-41     Citation Subset:  IM    
Cluain Mhuire Family Centre, Blackrock, Co Dublin, Ireland.
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MeSH Terms
Disease Models, Animal
Hippocampus / pathology*
Influenza A virus*
Mice, Inbred BALB C
Orthomyxoviridae Infections / pathology*
Prenatal Exposure Delayed Effects*
Pyramidal Cells / pathology*
Comment In:
Schizophr Res. 1996 Jul;21(1):63-4   [PMID:  8998277 ]

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