Document Detail


Does pregnancy immunize against breast cancer?
MedLine Citation:
PMID:  7538899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiparity has been linked with protection against breast cancer. T cells from biparous women, but not T cells from nulliparous women or men, specifically proliferated in response to core peptide sequences of a human breast cancer-associated mucin (MUC-1). Two of the nulliparous women were retested during the first trimester of their first pregnancy, and their T cells proliferated specifically in response to MUC-1 mucin. These observations support the hypothesis that there is a natural immunization against MUC-1 peptide epitopes during pregnancy which provides some protection against the development of breast cancer. These data also suggest that certain MUC-1 synthetic peptides might be effective components of "vaccines" for therapy or prevention of breast cancer.
Authors:
B Agrawal; M A Reddish; M J Krantz; B M Longenecker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  55     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-06-29     Completed Date:  1995-06-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2257-61     Citation Subset:  IM    
Affiliation:
Department of Immunology, University of Alberta, Edmonton, Canada.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Breast Neoplasms / immunology*,  prevention & control*
CD4-Positive T-Lymphocytes / cytology
Epitopes / immunology
Female
Humans
Lymphocyte Activation / drug effects,  immunology
Membrane Glycoproteins / immunology,  pharmacology*
Molecular Sequence Data
Mucin-1
Mucins / immunology,  pharmacology*
Parity
Peptide Fragments / pharmacology*
Pregnancy / blood,  immunology*
Sensitivity and Specificity
T-Lymphocyte Subsets
T-Lymphocytes / drug effects,  immunology
Chemical
Reg. No./Substance:
0/Epitopes; 0/Membrane Glycoproteins; 0/Mucin-1; 0/Mucins; 0/Peptide Fragments

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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