Document Detail

Does a preference for fatty foods prior to commencing treatment with the ketogenic diet predict the efficacy of this diet?
MedLine Citation:
PMID:  20655769     Owner:  NLM     Status:  MEDLINE    
The ketogenic diet can be effective in children who suffer from drug-resistant epilepsy. However, it is still hard to predict how large an effect this diet will have for an individual child. Previous data suggests a high-fat food preference is more likely in those with epilepsy, as assessed by in-person forced-choice design. The aim of this study is to examine whether a partiality to fatty foods prior to commencing the ketogenic diet can be used as a predictive factor for the efficacy of this diet in children with drug-resistant epilepsy. Data from 43 children aged between 2 and 19 years was used in this retrospective, non-controlled, non-randomised, open study. All children had followed the ketogenic diet for a period of 3 months or more. Before commencing the diet, a food record was collected for each child to determine the percentage of daily energy-intake accounted for by fats. Parents of the participants completed a questionnaire to measure fat-preference in the pre-diet period and received a score to objectify the efficacy of the treatment. The raw scores on the food record and on the questionnaire were divided into subgroups. Subsequently Kendall's tau-b was calculated for the correlation between each combination of variables. A non-significant correlation was found for the relationship between the food record and the questionnaire (p=.939), the relationship between the food record and the efficacy of the treatment (p=.827) and the relationship between the questionnaire and the efficacy of the treatment (p=.539). This means treatment efficacy cannot be predicted by the child's food preference.
C F Dekker; T A M van den Hurk; O van Nieuwenhuizen
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Publication Detail:
Type:  Journal Article     Date:  2010-07-23
Journal Detail:
Title:  Seizure     Volume:  19     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-06     Completed Date:  2010-12-02     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  421-5     Citation Subset:  IM    
Copyright Information:
2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Child, Preschool
Dietary Fats*
Epilepsy / diet therapy*
Food Preferences / physiology*
Ketogenic Diet*
Retrospective Studies
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Dietary Fats

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