Document Detail

Does potassium and magnesium supplementation lower the blood pressure of spontaneously hypertensive rats?
MedLine Citation:
PMID:  8169799     Owner:  NLM     Status:  MEDLINE    
The effects of an orally administered potassium and magnesium supplementation on the systolic blood pressure of 42 spontaneously hypertensive rats were determined for 10 weeks. The experimental preparation was mixed with standard rat pellets and this mixture was given to three rat groups at three concentrations: 6%, 9%, and 12%. Potassium- and magnesium-containing nutrient statistically significantly inhibited the normal increase in systolic blood pressure in these rats. It could even decrease the systolic blood pressure below the initial level and its effect was similar to the known calcium antagonist verapamil. The systolic blood pressure of rats fed with the standard pellet diet containing 6% sodium chloride (NaCl) increased from 191 to 209 mmHg, whereas that of animals on 6% K-Mg supplementation decreased from 197 to 181 mmHg. 9% and 12% K-Mg supplementation produced an almost equally significant decrease in systolic blood pressure, according to Student's unpaired t-test. The experimental nutrient could possibly be used in human studies on the feasibility of normalizing blood pressure by reducing the harmful effects of dietary salt.
J O Summanen; H J Vuorela; R K Hiltunen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  83     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-01     Completed Date:  1994-06-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-51     Citation Subset:  IM    
Department of Pharmacy, University of Helsinki, Finland.
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MeSH Terms
Blood Pressure / drug effects*
Depression, Chemical
Magnesium / pharmacology*
Potassium, Dietary / pharmacology*
Rats, Inbred SHR
Reg. No./Substance:
0/Potassium, Dietary; 7439-95-4/Magnesium

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