Document Detail


Does the pill make a difference? Previous maternal use of contraceptive pills and allergic diseases among offspring.
MedLine Citation:
PMID:  17073879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Maternal use of oral contraceptive pills (OCPs) might increase the prevalence of allergic diseases among offspring. The aim of the study was to clarify if there are differences between OCP types in this association. METHODS: Primary outcomes were asthma, allergic rhinitis and atopic eczema among 1182 children (618 asthmatic and 564 controls) aged 5-6 years. RESULTS: Maternal previous use of desogestrel, gestodene or cyproterone acetate before pregnancy, each combined with ethinyloestradiol (EO), increased the risk of allergic rhinitis among offspring compared with those children whose mothers had not used OCPs (OR 1.67, 95% CI 1.07-2.59, P < 0.024), and this risk was increased mainly in those children with parental allergy (OR 1.78, 95% CI 1.11-2.86, P < 0.018), especially in boys (OR 2.12, 95% CI 1.17-3.84, P < 0.014). No associations were observed between maternal use of OCPs before pregnancy and asthma or atopic eczema among offspring. The association between the previous use of OCPs and allergic rhinitis was not mediated through maternal sex steroid levels during early pregnancy, but women who had used more androgenic types of progestin formulas had higher serum levels of progesterone during early pregnancy. CONCLUSION: Maternal previous use of desogestrel, gestodene or cyproterone acetate before pregnancy, each combined with EO, increased the risk of allergic rhinitis among offspring compared with those children whose mothers had not used OCPs and this risk was detected mainly in boys and in children with parental allergy.
Authors:
L Keski-Nisula; J Pekkanen; B Xu; T Putus; P Koskela
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergy     Volume:  61     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2007-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1467-72     Citation Subset:  IM    
Affiliation:
Environmental Epidemiology Unit, National Public Health Institute, Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Child
Contraceptive Agents, Female / adverse effects*
Female
Humans
Hypersensitivity / etiology*
Male
Pregnancy
Prenatal Exposure Delayed Effects*
Chemical
Reg. No./Substance:
0/Contraceptive Agents, Female

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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