| Does periodontopathic bacterial infection contribute to the etiopathogenesis of the autoimmune disease rheumatoid arthritis? | |
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MedLine Citation:
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PMID: 22642916 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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There is a significant association between rheumatoid arthritis (RA) and periodontal disease (PD). Patients with longstanding active RA have been found to have a substantially increased frequency of PD compared with healthy subjects. Further, patients with PD have been shown to have a higher prevalence of RA than patients without periodontitis. Antibodies to Gram-negative, anaerobic periodontal pathogens such as Porphyromonas gingivalis, Prevotella intermedia, Prevotella melaninogenica, and Tannerella forsythia have been detected in the serum and synovial fluid of RA patients. These pathogens have also been identified in the synovial fluid of RA patients, with higher levels of bacterial DNA in RA patients than in controls. This review examines the association between periodontopathic bacteria and the etiology of RA. |
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Authors:
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Mesut Ogrendik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Discovery medicine Volume: 13 ISSN: 1944-7930 ISO Abbreviation: Discov Med Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101250006 Medline TA: Discov Med Country: United States |
Other Details:
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Languages: eng Pagination: 349-55 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Nazilli State Hospital, Nazilli 09800, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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