Document Detail

Does perinatal asphyxia contribute to neurological dysfunction in preterm infants?
MedLine Citation:
PMID:  20605570     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Children born preterm are known to be at risk for neurodevelopmental disorders. The role of perinatal asphyxia in this increased risk is still a matter of debate.
AIM: To analyze the contribution of perinatal asphyxia in a population of preterm infants admitted to a secondary paediatric setting to neurological dysfunction in the first months after birth and to the development of cerebral palsy.
METHODS: 17 preterm infants with perinatal asphyxia born before 35 weeks postmenstrual age (PMA) and 34 carefully matched preterm controls without asphyxia were studied. Neuromotor outcome was examined by means of three assessments of the quality of general movements (GM) at "preterm" (around 34 weeks PMA), "writhing" (around term age) and "fidgety" GM age (around 3 months post term). Follow-up until at least 18 months corrected age focused on the presence of cerebral palsy (CP).
RESULTS: GM-quality of infants with asphyxia and of those without did not differ. Multivariate analysis revealed that abnormal GMs at "preterm" age were associated with respiratory problems, those at "writhing" age with none of the assessed risk factors, and those at "fidgety" age with the severity of periventricular leukomalacia (PVL) on neonatal ultrasound scan. Perinatal asphyxia was not associated with the development of CP. CP was associated with PVL and the presence of abnormal GMs at "fidgety" age.
CONCLUSION: Perinatal asphyxia in preterm infants is not associated with an increased risk for neurodevelopmental problems including CP. Respiratory problems during the neonatal period are associated with PVL and adverse neurological outcome.
Patricia A M van Iersel; Saskia C M Bakker; Arnold J H Jonker; Mijna Hadders-Algra
Publication Detail:
Type:  Journal Article     Date:  2010-07-06
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  457-61     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ltd. All rights reserved.
Gelre Hospital, Department of Physical Therapy, Apeldoorn, The Netherlands.
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MeSH Terms
Asphyxia Neonatorum / complications*
Cerebral Palsy / epidemiology,  etiology*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology,  etiology*
Leukomalacia, Periventricular / epidemiology,  etiology
Nervous System Diseases / epidemiology,  etiology
Risk Assessment
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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