| Does parathyroid hormone affect erythropoietin therapy in dialysis patients? | |
| | |
MedLine Citation:
|
PMID: 17159367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The objective of this study was to assess the response to recombinant human erythropoietin (rHuEPO) during treatment of anemia in dialysis patients with hyperparathyroidism. SUBJECTS AND METHODS: A total of 118 patients with stage 5 renal failure on dialysis therapy were selected for this study. Anemia was treated with rHuEPO. Laboratory data for each patient included intact parathyroid hormone (iPTH), hemoglobin (Hb), hematocrit (Hct), blood urea nitrogen, serum creatinine, calcium, phosphate, and alkaline phosphatase. Patients with iPTH >32 pmol/l were considered hyperparathyroid. Erythropoietin resistance index (ERI) was expressed as the ratio of weekly rHuEPO dose/Hct level. RESULTS: Of the 118 patients, 83 (70.3%) were on hemodialysis (HD) and 35 (29.7%) were on continuous ambulatory peritoneal dialysis (CAPD). Sixty-three patients (64.3%) with iPTH >32 pmol/l had Hb <11 g/dl, while 34 (54.8%) with iPTH <32 had Hb >11 g/dl (p = 04). Thirty-three (56%) patients with iPTH >32 pmol/l had hemocrit <33%, while 38 (61.3%) with iPTH <32 had hemocrit <33% (p = 0.4). The median value of weekly rHuEPO dose in HD patients (12,000 units) was significantly higher in comparison with CAPD patients (6,000 units; p < 0.0001). ERI was significantly higher in HD than CAPD patients with iPTH <16 pmol/l (p = 0002) as well as with patients with 16-32 pmol/l (p = 0.012). CONCLUSIONS: CAPD patients showed a reduced requirement for rHuEPO and better control of anemia compared with HD patients. ERI was also lower in CAPD than in HD patients. Hyperparathyroidism is a parameter predictive of rHuEPO hyporesponsiveness in dialysis patients. |
| | |
Authors:
|
Nabieh Al-Hilali; Hani Al-Humoud; Vadakethu T Ninan; Mangalathillam R N Nampoory; Mini A Puliyclil; Kaivilayil V Johny |
Related Documents
:
|
22230647 - Effects of lithium therapy on na(+)-k(+)-atpase activity and lipid peroxidation in bipo... 17603977 - A thrice weekly in-center nocturnal hemodialysis program. 8865917 - Is an elevated level of serum lipoprotein (a) a risk factor for cardiovascular disease ... 793647 - Rosette forming t-cells in human lymphomas: relationship with age and clinical parameters. 17959637 - Virological diagnosis in community-acquired pneumonia in immunocompromised patients. 23167997 - Evaluation of the who revised criteria for classification of clinical disease severity ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Medical principles and practice : international journal of the Kuwait University, Health Science Centre Volume: 16 ISSN: 1011-7571 ISO Abbreviation: Med Princ Pract Publication Date: 2007 |
Date Detail:
|
Created Date: 2006-12-12 Completed Date: 2007-02-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8901334 Medline TA: Med Princ Pract Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 63-7 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2007 S. Karger AG, Basel. |
Affiliation:
|
Department of Medicine, Mubarak Al-Kabeer Hospital, Kuwait. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Anemia / drug therapy* Erythropoietin / therapeutic use* Female Humans Hyperparathyroidism* Male Middle Aged Parathyroid Hormone / blood Peritoneal Dialysis, Continuous Ambulatory* Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
|
0/Parathyroid Hormone; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Occurrence of Campylobacter jejuni in Shiraz, Southwest Iran.
Next Document: Hydatid disease of the first rib causing thoracic outlet syndrome.